PI3K is Negatively Regulated by PIK3IP1, a Novel P110 Interacting Protein

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 2007 May 4

PMID 17475214

Citations 47

Authors

Zhenqi Zhu

Xin He

Carla Johnson

John Stoops

Amanda E Eaker

David S Stoffer

Aaron Bell

Reza Zarnegar

Marie C DeFrances

Affiliations

Soon will be listed here.

Abstract

Signaling initiated by Class Ia phosphatidylinositol-3-kinases (PI3Ks) is essential for cell proliferation and survival. We discovered a novel protein we call PI3K interacting protein 1 (PIK3IP1) that shares homology with the p85 regulatory PI3K subunit. Using a variety of in vitro and cell based assays, we demonstrate that PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Our studies suggest that PIK3IP1 is a new type of PI3K regulator.

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