Optical Tomography of the Neonatal Brain

Overview

Journal Eur Radiol

Specialty Radiology

Date 2007 May 3

PMID 17473923

Citations 9

Authors

Jeremy C Hebden

Topun Austin

Affiliations

Soon will be listed here.

Abstract

A new method of assessing neurological function and pathology in the newborn infant is being developed based on the transmission of near-infrared light across the brain. Absorption by blood over a range of wavelengths reveals a strong dependency on oxygenation status, and measurements of transmitted light enable the spatial variation in the concentrations of the oxygenated and de-oxygenated forms of hemoglobin to be derived. Optical tomography has so far provided static three-dimensional maps of blood volume and oxygenation as well as dynamic images revealing the brain's response to sensory stimulation and global hemodynamic changes. The imaging modality is being developed as a safe and non-invasive tool that can be utilized at the cotside in intensive care. Optical tomography of the healthy infant brain is also providing a means of studying neurophysiological processes during early development and the potential consequences of prematurity.

Citing Articles

In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage.

Jiang J, Lindner S, Di Costanzo-Mata A, Zhang C, Charbon E, Wolf M Adv Exp Med Biol. 2021; 1269:341-346.

PMID: 33966240 DOI: 10.1007/978-3-030-48238-1_54.

Review of Biomedical Applications of Contactless Imaging of Neonates Using Infrared Thermography and Beyond.

AlZubaidi A, Ethawi Y, Schmolzer G, Sherif S, Narvey M, Seshia M Methods Protoc. 2019; 1(4).

PMID: 31164579 PMC: 6481091. DOI: 10.3390/mps1040039.

Spectral correction for handheld optoacoustic imaging by means of near-infrared optical tomography in reflection mode.

Ulrich L, Ahnen L, Akarcay H, Sanchez Majos S, Jaeger M, Held K J Biophotonics. 2018; 12(1):e201800112.

PMID: 30098119 PMC: 7065640. DOI: 10.1002/jbio.201800112.

Hyperspectral optical tomography of intrinsic signals in the rat cortex.

Konecky S, Wilson R, Hagen N, Mazhar A, Tkaczyk T, Frostig R Neurophotonics. 2016; 2(4):045003.

PMID: 26835483 PMC: 4718192. DOI: 10.1117/1.NPh.2.4.045003.

Diffuse Optics for Tissue Monitoring and Tomography.

Durduran T, Choe R, Baker W, Yodh A Rep Prog Phys. 2015; 73(7).

PMID: 26120204 PMC: 4482362. DOI: 10.1088/0034-4885/73/7/076701.

References

Marlow N, Wolke D, Bracewell M, Samara M . Neurologic and developmental disability at six years of age after extremely preterm birth. N Engl J Med. 2005; 352(1):9-19. DOI: 10.1056/NEJMoa041367. View

Brazy J, Lewis D, Mitnick M, Jobsis Vander Vliet F . Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations. Pediatrics. 1985; 75(2):217-25. View

Arridge S, Lionheart W . Nonuniqueness in diffusion-based optical tomography. Opt Lett. 2007; 23(11):882-4. DOI: 10.1364/ol.23.000882. View

Gibson A, Austin T, Everdell N, Schweiger M, Arridge S, Meek J . Three-dimensional whole-head optical tomography of passive motor evoked responses in the neonate. Neuroimage. 2005; 30(2):521-8. DOI: 10.1016/j.neuroimage.2005.08.059. View

Hintz S, Cheong W, van Houten J, Stevenson D, Benaron D . Bedside imaging of intracranial hemorrhage in the neonate using light: comparison with ultrasound, computed tomography, and magnetic resonance imaging. Pediatr Res. 1999; 45(1):54-9. DOI: 10.1203/00006450-199901000-00009. View

Hebden J, Gibson A, Austin T, Yusof R, Everdell N, Delpy D . Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography. Phys Med Biol. 2004; 49(7):1117-30. DOI: 10.1088/0031-9155/49/7/003. View

Austin T, Gibson A, Branco G, Yusof R, Arridge S, Meek J . Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain. Neuroimage. 2006; 31(4):1426-33. DOI: 10.1016/j.neuroimage.2006.02.038. View

Kotilahti K, Nissila I, Huotilainen M, Makela R, Gavrielides N, Noponen T . Bilateral hemodynamic responses to auditory stimulation in newborn infants. Neuroreport. 2005; 16(12):1373-7. DOI: 10.1097/01.wnr.0000175247.35837.15. View

Ferrari M, Mottola L, Quaresima V . Principles, techniques, and limitations of near infrared spectroscopy. Can J Appl Physiol. 2004; 29(4):463-87. DOI: 10.1139/h04-031. View

10.

Powers W, Press G, Grubb Jr R, Gado M, Raichle M . The effect of hemodynamically significant carotid artery disease on the hemodynamic status of the cerebral circulation. Ann Intern Med. 1987; 106(1):27-34. DOI: 10.7326/0003-4819-106-1-27. View

11.

Martin E, Joeri P, Loenneker T, Ekatodramis D, Vitacco D, Hennig J . Visual processing in infants and children studied using functional MRI. Pediatr Res. 1999; 46(2):135-40. DOI: 10.1203/00006450-199908000-00001. View

12.

Arridge S . Photon-measurement density functions. Part I: Analytical forms. Appl Opt. 2010; 34(31):7395-409. DOI: 10.1364/AO.34.007395. View

13.

Taga G, Konishi Y, Maki A, Tachibana T, Fujiwara M, Koizumi H . Spontaneous oscillation of oxy- and deoxy- hemoglobin changes with a phase difference throughout the occipital cortex of newborn infants observed using non-invasive optical topography. Neurosci Lett. 2000; 282(1-2):101-4. DOI: 10.1016/s0304-3940(00)00874-0. View

14.

Gibson A, Hebden J, Arridge S . Recent advances in diffuse optical imaging. Phys Med Biol. 2005; 50(4):R1-43. DOI: 10.1088/0031-9155/50/4/r01. View

15.

Culver J, Choe R, Holboke M, Zubkov L, Durduran T, Slemp A . Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging. Med Phys. 2003; 30(2):235-47. DOI: 10.1118/1.1534109. View

16.

Hintz S, Benaron D, van Houten J, Duckworth J, Liu F, Spilman S . Stationary headband for clinical time-of-flight optical imaging at the bedside. Photochem Photobiol. 1998; 68(3):361-9. View

17.

JOBSIS F . Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science. 1977; 198(4323):1264-7. DOI: 10.1126/science.929199. View

18.

Pogue B, Testorf M, McBride T, Osterberg U, Paulsen K . Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection. Opt Express. 2009; 1(13):391-403. DOI: 10.1364/oe.1.000391. View

19.

Meek J, Firbank M, Elwell C, Atkinson J, Braddick O, Wyatt J . Regional hemodynamic responses to visual stimulation in awake infants. Pediatr Res. 1998; 43(6):840-3. DOI: 10.1203/00006450-199806000-00019. View

20.

Gibson A, Yusof R, Dehghani H, Riley J, Everdell N, Richards R . Optical tomography of a realistic neonatal head phantom. Appl Opt. 2003; 42(16):3109-16. DOI: 10.1364/ao.42.003109. View