Manganese: Recent Advances in Understanding Its Transport and Neurotoxicity

Overview

Journal Toxicol Appl Pharmacol

Specialties Pharmacology
Toxicology

Date 2007 May 1

PMID 17466353

Citations 190

Authors

Michael Aschner

Tomas R Guilarte

Jay S Schneider

Wei Zheng

Affiliations

Soon will be listed here.

Abstract

The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans.

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