P300 Cognitive Evoked Potentials Before and After Liver Transplantation

Overview

Journal Metab Brain Dis

Publisher Springer

Specialties Endocrinology
Neurology

Date 2007 Apr 26

PMID 17457666

Citations 2

Authors

Roy R Reeves

Frederick A Struve

Carla J Rash

Randy S Burke

Affiliations

Soon will be listed here.

Abstract

P300 cognitive evoked potentials have been shown to be effective for the assessment of mild hepatic encephalopathy but no investigations of their use with liver transplantation has been conducted. In this pilot study 12 subjects (7 male, 5 female, average age 43.9-years-old) underwent recording of auditory and visual P300 cognitive evoked potentials prior to liver transplantation and again 3-6 months subsequent to transplantation. Significant increases (p < 0.01) in P300 visual amplitude, as well as significant decreases in visual (p < 0.01) and auditory latencies (p < 0.01) were observed following transplantation. Auditory amplitudes increased but not to a statistically significant degree. P300 cognitive evoked potentials may provide a useful tool for monitoring the cerebral status of liver transplantation patients if combined with established methods such as cognitive testing and EEG. Further research of their usage with these patients is warranted.

Citing Articles

Modulation of neural activation following treatment of hepatic encephalopathy.

McPhail M, Leech R, Grover V, Fitzpatrick J, Dhanjal N, Crossey M Neurology. 2013; 80(11):1041-7.

PMID: 23427320 PMC: 3653205. DOI: 10.1212/WNL.0b013e31828726e1.

Neurocognitive-neurological complications of liver transplantation: a review.

Campagna F, Biancardi A, Cillo U, Gatta A, Amodio P Metab Brain Dis. 2010; 25(1):115-24.

PMID: 20204483 DOI: 10.1007/s11011-010-9183-0.

References

Watanabe A . Cerebral changes in hepatic encephalopathy. J Gastroenterol Hepatol. 1998; 13(7):752-60. DOI: 10.1111/j.1440-1746.1998.tb00728.x. View

Davies M, Rowan M, Feely J . EEG and event related potentials in hepatic encephalopathy. Metab Brain Dis. 1991; 6(4):175-86. DOI: 10.1007/BF00996917. View

Gallai V, Alberti A, Balo S, Mazzotta G, Clerici C, Gentili G . Cognitive event-related potential in hepatic encephalopathy. Acta Neurol Scand. 1995; 91(5):358-61. DOI: 10.1111/j.1600-0404.1995.tb07021.x. View

Saxena N, Bhatia M, Joshi Y, Garg P, Dwivedi S, Tandon R . Electrophysiological and neuropsychological tests for the diagnosis of subclinical hepatic encephalopathy and prediction of overt encephalopathy. Liver. 2002; 22(3):190-7. DOI: 10.1034/j.1600-0676.2002.01431.x. View

Kugler C, TAGHAVY A, Fleig W, Hahn E . [Visual P300 in acute hepatic encephalopathy resulting from non-A-non-B fulminant hepatitis: analysis of the course before and after orthotopic liver transplantation]. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1991; 22(4):259-63. View

Amodio P, Gatta A . Neurophysiological investigation of hepatic encephalopathy. Metab Brain Dis. 2005; 20(4):369-79. DOI: 10.1007/s11011-005-7921-5. View

CONN H . Trailmaking and number-connection tests in the assessment of mental state in portal systemic encephalopathy. Am J Dig Dis. 1977; 22(6):541-50. DOI: 10.1007/BF01072510. View

Davies M, Rowan M, MacMathuna P, Keeling P, Weir D, Feely J . The auditory P300 event-related potential: an objective marker of the encephalopathy of chronic liver disease. Hepatology. 1990; 12(4 Pt 1):688-94. DOI: 10.1002/hep.1840120412. View

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

10.

Pugh R, Murray-Lyon I, Dawson J, Pietroni M, Williams R . Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973; 60(8):646-9. DOI: 10.1002/bjs.1800600817. View

11.

Montagnese S, Amodio P, Morgan M . Methods for diagnosing hepatic encephalopathy in patients with cirrhosis: a multidimensional approach. Metab Brain Dis. 2004; 19(3-4):281-312. DOI: 10.1023/b:mebr.0000043977.11113.2a. View

12.

Saxena N, Bhatia M, Joshi Y, Garg P, Tandon R . Auditory P300 event-related potentials and number connection test for evaluation of subclinical hepatic encephalopathy in patients with cirrhosis of the liver: a follow-up study. J Gastroenterol Hepatol. 2001; 16(3):322-7. DOI: 10.1046/j.1440-1746.2001.02388.x. View

13.

Kugler C, Lotterer E, Petter J, Wensing G, TAGHAVY A, Hahn E . Visual event-related P300 potentials in early portosystemic encephalopathy. Gastroenterology. 1992; 103(1):302-10. DOI: 10.1016/0016-5085(92)91127-p. View

14.

Hollerbach S, Kullmann F, Frund R, Lock G, Geissler A, Scholmerich J . Auditory event-related cerebral potentials (P300) in hepatic encephalopathy--topographic distribution and correlation with clinical and psychometric assessment. Hepatogastroenterology. 1997; 44(16):1002-12. View

15.

Sexena N, Bhatia M, Yoshi Y, Garg P, Tandon R . Utility of P300 auditory event related potential in detecting cognitive dysfunction in patients with cirrhosis of the liver. Neurol India. 2002; 49(4):350-4. View

16.

Trzepacz P, Maue F, Coffman G, Van Thiel D . Neuropsychiatric assessment of liver transplantation candidates: delirium and other psychiatric disorders. Int J Psychiatry Med. 1986; 16(2):101-11. DOI: 10.2190/h39m-5utc-hy87-bpx9. View