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Non-synonymous Polymorphisms in the Circadian Gene NPAS2 and Breast Cancer Risk

Overview
Specialty Oncology
Date 2007 Apr 25
PMID 17453337
Citations 55
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Abstract

Three known non-synonymous polymorphisms (Ala394Thr, Ser471Leu and Pro690Ala) in the largest circadian gene, Neuronal PAS domain protein 2 (NPAS2), were genotyped in a breast cancer case-control study conducted in Connecticut, USA (431 cases and 476 controls). We found that women with the heterozygous Ala394Thr genotype were significantly associated with breast cancer risk compared to those with the common homozygous Ala394Ala (OR = 0.61, 0.46-0.81, P = 0.001). This is the first evidence demonstrating a role of the circadian gene NPAS2 in human breast cancer, suggesting that genetic variations in circadian genes might be a novel panel of biomarkers for breast cancer risk.

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References
1.
Johansson C, Willeit M, Smedh C, Ekholm J, Paunio T, Kieseppa T . Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology. 2003; 28(4):734-9. DOI: 10.1038/sj.npp.1300121. View

2.
Fu L, Pelicano H, Liu J, Huang P, Lee C . The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell. 2002; 111(1):41-50. DOI: 10.1016/s0092-8674(02)00961-3. View

3.
Fu L, Lee C . The circadian clock: pacemaker and tumour suppressor. Nat Rev Cancer. 2003; 3(5):350-61. DOI: 10.1038/nrc1072. View

4.
Dudley C, Erbel-Sieler C, Estill S, Reick M, Franken P, Pitts S . Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science. 2003; 301(5631):379-83. DOI: 10.1126/science.1082795. View

5.
Koyanagi S, Kuramoto Y, Nakagawa H, Aramaki H, Ohdo S, Soeda S . A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells. Cancer Res. 2003; 63(21):7277-83. View