Modifiers of Epigenetic Reprogramming Show Paternal Effects in the Mouse

Overview

Journal Nat Genet

Specialty Genetics

Date 2007 Apr 24

PMID 17450140

Citations 72

Authors

Suyinn Chong

Nicola Vickaryous

Alyson Ashe

Natasha Zamudio

Neil Youngson

Sarah Hemley

Tomas Stopka

Arthur Skoultchi

Jacqui Matthews

Hamish S Scott

David de Kretser

Moira OBryan

Marnie Blewitt

Emma Whitelaw

Affiliations

Soon will be listed here.

Abstract

There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur following paternal inheritance in the mouse. We detected changes to transcription and chromosome ploidy in adult animals. Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring.

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