Candidate Gene Association Study of Insulin Signaling Genes and Alzheimer's Disease: Evidence for SOS2, PCK1, and PPARgamma As Susceptibility Loci

Overview

Journal Am J Med Genet B Neuropsychiatr Genet

Specialties Genetics
Neurology
Psychiatry

Date 2007 Apr 19

PMID 17440948

Citations 26

Authors

Gillian Hamilton

Petra Proitsi

Luke Jehu

Angharad Morgan

Julie Williams

Michael C ODonovan

Michael J Owen

John F Powell

Simon Lovestone

Affiliations

Soon will be listed here.

Abstract

Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender.

Citing Articles

Sperm chromatin accessibility's involvement in the intergenerational effects of stress hormone receptor activation.

Fischer V, Kretschmer M, Germain P, Kaur J, Mompart-Barrenechea S, Pelczar P Transl Psychiatry. 2023; 13(1):378.

PMID: 38065942 PMC: 10709351. DOI: 10.1038/s41398-023-02684-z.

Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci.

Jaholkowski P, Hindley G, Shadrin A, Tesfaye M, Bahrami S, Nerhus M Schizophr Bull. 2023; 49(6):1654-1664.

PMID: 37163672 PMC: 10686370. DOI: 10.1093/schbul/sbad063.

Dementia clinical trials over the past decade: are women fairly represented?.

Pinho-Gomes A, Gong J, Harris K, Woodward M, Carcel C BMJ Neurol Open. 2022; 4(2):e000261.

PMID: 36110923 PMC: 9445798. DOI: 10.1136/bmjno-2021-000261.

SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology.

Baltanas F, Garcia-Navas R, Santos E Int J Mol Sci. 2021; 22(12).

PMID: 34205562 PMC: 8234257. DOI: 10.3390/ijms22126613.

Ras GEF Mouse Models for the Analysis of Ras Biology and Signaling.

Fernandez-Medarde A, Santos E Methods Mol Biol. 2021; 2262:361-395.

PMID: 33977490 DOI: 10.1007/978-1-0716-1190-6_23.