Human Herpesvirus 6 Subtype A-associated Myocarditis with 'apical Ballooning'

Overview

Journal Can J Cardiol

Publisher Elsevier

Specialty Cardiology & Vascular Diseases

Date 2007 Apr 19

PMID 17440647

Citations 9

Authors

Boris Bigalke

Karin Klingel

Andreas E May

Reinhard Kandolf

Meinrad Gawaz Gawaz

Affiliations

Soon will be listed here.

Abstract

A 67-year-old woman who presented with acute chest pain is reported. Three days before admission, she suffered from a flu-like infection. Coronary angiography showed no coronary stenosis. Ventriculography showed moderately reduced left ventricular function characterized by the so-called 'apical ballooning'. Endomyocardial biopsies and polymerase chain reaction analysis of the plasma revealed an acute infection with human herpesvirus 6 subtype A. Histological and immunohistochemical analyses revealed myocarditis with areas of interstitial macrophages and fibrosis. The present case report links, for the first time, myocarditis with a human herpesvirus 6 subtype A infection and the appearance of apical ballooning.

Citing Articles

Endomyocardial biopsy-proven fulminant lymphocytic myocarditis presenting with mid-apical ballooning.

Miyamoto R, Ise T, Yoshida T, Sata M Eur Heart J Case Rep. 2023; 7(3):ytad123.

PMID: 37006797 PMC: 10057820. DOI: 10.1093/ehjcr/ytad123.

Myocarditis presenting as typical acute myocardial infarction: A case report and review of the literature.

Hou Y, Han P, Wu X, Lin J, Zheng F, Lin L World J Clin Cases. 2020; 8(2):415-424.

PMID: 32047794 PMC: 7000954. DOI: 10.12998/wjcc.v8.i2.415.

Complete Genome Sequence of Germline Chromosomally Integrated Human Herpesvirus 6A and Analyses Integration Sites Define a New Human Endogenous Virus with Potential to Reactivate as an Emerging Infection.

Tweedy J, Spyrou M, Pearson M, Lassner D, Kuhl U, Gompels U Viruses. 2016; 8(1).

PMID: 26784220 PMC: 4728579. DOI: 10.3390/v8010019.

Acute myocarditis mimicking ST-elevation myocardial infarction: A case report and review of the literature.

Zhang T, Miao W, Wang S, Wei M, Su G, Li Z Exp Ther Med. 2015; 10(2):459-464.

PMID: 26622337 PMC: 4508986. DOI: 10.3892/etm.2015.2576.

Human Herpesvirus 6A U14 Is Important for Virus Maturation.

Mori J, Tang H, Kawabata A, Koike M, Mori Y J Virol. 2015; 90(3):1677-81.

PMID: 26559847 PMC: 4719638. DOI: 10.1128/JVI.02492-15.

References

Kuhl U, Pauschinger M, Noutsias M, Seeberg B, Bock T, Lassner D . High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction. Circulation. 2005; 111(7):887-93. DOI: 10.1161/01.CIR.0000155616.07901.35. View

Ward K . The natural history and laboratory diagnosis of human herpesviruses-6 and -7 infections in the immunocompetent. J Clin Virol. 2005; 32(3):183-93. DOI: 10.1016/j.jcv.2004.11.008. View

Tomonari A, Takahashi S, Ooi J, Takasugi K, Konuma T, Iseki T . Human herpesvirus 6 variant A infection with fever, skin rash, and liver dysfunction in a patient after unrelated cord blood transplantation. Bone Marrow Transplant. 2005; 36(12):1109-10. DOI: 10.1038/sj.bmt.1705184. View

Kurisu S, Sato H, Kawagoe T, Ishihara M, Shimatani Y, Nishioka K . Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute myocardial infarction. Am Heart J. 2002; 143(3):448-55. DOI: 10.1067/mhj.2002.120403. View

Mori Y, Seya T, Huang H, Akkapaiboon P, Dhepakson P, Yamanishi K . Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46. J Virol. 2002; 76(13):6750-61. PMC: 136280. DOI: 10.1128/jvi.76.13.6750-6761.2002. View

Caruso A, Rotola A, Comar M, Favilli F, Galvan M, Tosetti M . HHV-6 infects human aortic and heart microvascular endothelial cells, increasing their ability to secrete proinflammatory chemokines. J Med Virol. 2002; 67(4):528-33. DOI: 10.1002/jmv.10133. View

Stodberg T, Deniz Y, Esteitie N, Jacobsson B, Mousavi-Jazi M, Dahl H . A case of diffuse leptomeningeal oligodendrogliomatosis associated with HHV-6 variant A. Neuropediatrics. 2003; 33(5):266-70. DOI: 10.1055/s-2002-36739. View

Grivel J, Santoro F, Chen S, Faga G, Malnati M, Ito Y . Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo. J Virol. 2003; 77(15):8280-9. PMC: 165251. DOI: 10.1128/jvi.77.15.8280-8289.2003. View

Abe Y, Kondo M . Apical ballooning of the left ventricle: a distinct entity?. Heart. 2003; 89(9):974-6. PMC: 1767830. DOI: 10.1136/heart.89.9.974. View

10.

Freitas R, Freitas M, Linhares A . Evidence of active herpesvirus 6 (variant-A) infection in patients with lymphadenopathy in Belém, Pará, Brazil. Rev Inst Med Trop Sao Paulo. 2004; 45(5):283-8. DOI: 10.1590/s0036-46652003000500008. View

11.

Enomoto M, Ochi M, Teramae K, Kamo R, Taguchi S, Yamane T . Codeine phosphate-induced hypersensitivity syndrome. Ann Pharmacother. 2004; 38(5):799-802. DOI: 10.1345/aph.1D528. View

12.

Bybee K, Kara T, Prasad A, Lerman A, Barsness G, Wright R . Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med. 2004; 141(11):858-65. DOI: 10.7326/0003-4819-141-11-200412070-00010. View

13.

De Bolle L, Naesens L, De Clercq E . Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev. 2005; 18(1):217-45. PMC: 544175. DOI: 10.1128/CMR.18.1.217-245.2005. View

14.

Borghi E, Pagani E, Mancuso R, Delbue S, Valli M, Mazziotti R . Detection of herpesvirus-6A in a case of subacute cerebellitis and myoclonic dystonia. J Med Virol. 2005; 75(3):427-9. DOI: 10.1002/jmv.20285. View

15.

Mitani N, Aihara M, Yamakawa Y, Yamada M, Itoh N, Mizuki N . Drug-induced hypersensitivity syndrome due to cyanamide associated with multiple reactivation of human herpesviruses. J Med Virol. 2005; 75(3):430-4. DOI: 10.1002/jmv.20295. View

16.

Birnbaum T, Padovan C, Sporer B, Rupprecht T, Ausserer H, Jaeger G . Severe meningoencephalitis caused by human herpesvirus 6 type B in an immunocompetent woman treated with ganciclovir. Clin Infect Dis. 2005; 40(6):887-9. DOI: 10.1086/427943. View