Improved Biochemical Strategies for Targeted Delivery of Taxoids

Overview

Journal Bioorg Med Chem

Specialties Biochemistry
Chemistry

Date 2007 Apr 10

PMID 17419065

Citations 13

Authors

Thota Ganesh

Affiliations

Soon will be listed here.

Abstract

Paclitaxel (Taxol) and docetaxel (Taxotere) are very important anti-tumor drugs in clinical use for cancer. However, their clinical utility is limited due to systemic toxicity, low solubility and inactivity against drug resistant tumors. To improve chemotherapeutic levels of these drugs, it would be highly desirable to design strategies which bypass the above limitations. In this respect various prodrug and drug targeting strategies have been envisioned either to improve oral bioavailability or tumor specific delivery of taxoids. Abnormal properties of cancer cells with respect to normal cells have guided in designing of these protocols. This review article records the designed biochemical strategies and their biological efficacies as potential taxoid chemotherapeutics.

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References

Lee J, Lu J, Low P, Fuchs P . Synthesis and evaluation of taxol-folic acid conjugates as targeted antineoplastics. Bioorg Med Chem. 2002; 10(7):2397-414. DOI: 10.1016/s0968-0896(02)00019-6. View

Zhou J, Chen J, Mokotoff M, Zhong R, Shultz L, Ball E . Bombesin/gastrin-releasing peptide receptor: a potential target for antibody-mediated therapy of small cell lung cancer. Clin Cancer Res. 2003; 9(13):4953-60. View

Haenseler E, Esswein A, Vitols K, Montejano Y, Mueller B, Reisfeld R . Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate. Biochemistry. 1992; 31(3):891-7. DOI: 10.1021/bi00118a035. View

Arteaga C . Epidermal growth factor receptor dependence in human tumors: more than just expression?. Oncologist. 2002; 7 Suppl 4:31-9. DOI: 10.1634/theoncologist.7-suppl_4-31. View

Saari W, Schwering J, Lyle P, Smith S, Engelhardt E . Cyclization-activated prodrugs. Basic carbamates of 4-hydroxyanisole. J Med Chem. 1990; 33(1):97-101. DOI: 10.1021/jm00163a016. View

Cave Jr W . Dietary n-3 (omega-3) polyunsaturated fatty acid effects on animal tumorigenesis. FASEB J. 1991; 5(8):2160-6. DOI: 10.1096/fasebj.5.8.1673664. View

Dillman R . Monoclonal antibodies in the treatment of malignancy: basic concepts and recent developments. Cancer Invest. 2002; 19(8):833-41. DOI: 10.1081/cnv-100107745. View

Crown J, OLeary M, Ooi W . Docetaxel and paclitaxel in the treatment of breast cancer: a review of clinical experience. Oncologist. 2004; 9 Suppl 2:24-32. DOI: 10.1634/theoncologist.9-suppl_2-24. View

Hood K, West L, Rouwe B, Northcote P, Berridge M, Wakefield S . Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity. Cancer Res. 2002; 62(12):3356-60. View

10.

Greenwald R, Gilbert C, Pendri A, Conover C, Xia J, Martinez A . Drug delivery systems: water soluble taxol 2'-poly(ethylene glycol) ester prodrugs-design and in vivo effectiveness. J Med Chem. 1996; 39(2):424-31. DOI: 10.1021/jm950475e. View

11.

Klibanov A, Maruyama K, Torchilin V, Huang L . Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 1990; 268(1):235-7. DOI: 10.1016/0014-5793(90)81016-h. View

12.

Theti D, Jackman A . The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs. Clin Cancer Res. 2004; 10(3):1080-9. DOI: 10.1158/1078-0432.ccr-03-0157. View

13.

Jones M, Leroux J . Polymeric micelles - a new generation of colloidal drug carriers. Eur J Pharm Biopharm. 1999; 48(2):101-11. DOI: 10.1016/s0939-6411(99)00039-9. View

14.

Carl P, CHAKRAVARTY P, Katzenellenbogen J, Weber M . Protease-activated "prodrugs" for cancer chemotherapy. Proc Natl Acad Sci U S A. 1980; 77(4):2224-8. PMC: 348685. DOI: 10.1073/pnas.77.4.2224. View

15.

Wang C, Thor A, Moore 2nd D, Zhao Y, Kerschmann R, Stern R . The overexpression of RHAMM, a hyaluronan-binding protein that regulates ras signaling, correlates with overexpression of mitogen-activated protein kinase and is a significant parameter in breast cancer progression. Clin Cancer Res. 1998; 4(3):567-76. View

16.

Udabage L, Brownlee G, Nilsson S, Brown T . The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer. Exp Cell Res. 2005; 310(1):205-17. DOI: 10.1016/j.yexcr.2005.07.026. View

17.

Liu C, Strobl J, Bane S, Schilling J, McCracken M, Chatterjee S . Design, synthesis, and bioactivities of steroid-linked taxol analogues as potential targeted drugs for prostate and breast cancer. J Nat Prod. 2004; 67(2):152-9. DOI: 10.1021/np030296x. View

18.

Jaracz S, Chen J, Kuznetsova L, Ojima I . Recent advances in tumor-targeting anticancer drug conjugates. Bioorg Med Chem. 2005; 13(17):5043-54. DOI: 10.1016/j.bmc.2005.04.084. View

19.

Visaria R, Griffin R, Williams B, Ebbini E, Paciotti G, Song C . Enhancement of tumor thermal therapy using gold nanoparticle-assisted tumor necrosis factor-alpha delivery. Mol Cancer Ther. 2006; 5(4):1014-20. DOI: 10.1158/1535-7163.MCT-05-0381. View

20.

Luo Y, Prestwich G . Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate. Bioconjug Chem. 1999; 10(5):755-63. DOI: 10.1021/bc9900338. View