Alpha 2.0
Login Register
» Articles » PMID: 17415524

FABP7 Expression in Glioblastomas: Relation to Prognosis, Invasion and EGFR Status

Overview
Journal J Neurooncol
Publisher Springer
Date 2007 Apr 7
PMID 17415524
Citations 39
Authors
Gentian Kaloshi
Karima Mokhtari
Catherine Carpentier
Sophie Taillibert
Julie Lejeune
Yannick Marie
Jean-Yves Delattre
Roseline Godbout
Marc Sanson
Affiliations
Soon will be listed here.
Abstract

FABP7 expression has been analysed in a series of 123 glioblastomas (68 pure GBM, 55 GBMO, i.e. with oligodendroglial component). FABP7, found in 91/123 samples, showed a pure cytoplasmic expression in 69 cases, and cytoplasmic+nuclear expression in 22 cases. FABP7 expression was associated with pure GBM histology and shorter survival (15.7 months versus 21.5 months). Nuclear expression of FABP7 was more specifically related to EGFR amplification and more invasive tumors. These data, although they need to be confirmed by further studies, support the relation between FABP7, astrocytic features, invasion and poor prognosis and suggests that EGFR amplification is associated with nuclear translocation of FABP7.

Citing Articles

Integrated Transcriptome Profiling and Pan-Cancer Analyses Reveal Oncogenic Networks and Tumor-Immune Modulatory Roles for FABP7 in Brain Cancers.

Lee Y, Flores C, Lefton M, Bhoumik S, Owada Y, Gerstner J Int J Mol Sci. 2024; 25(22).

PMID: 39596296 PMC: 11594725. DOI: 10.3390/ijms252212231.

FABP7: A Potential Diagnostic and Prognostic Biomarker for Clear Cell Renal Cell Carcinoma.

Panwoon C, Seubwai W, Thanee M, Sangkhamanon S In Vivo. 2024; 38(6):2912-2920.

PMID: 39477380 PMC: 11535899. DOI: 10.21873/invivo.13773.

Stationary-to-migratory transition in glioblastoma stem-like cells driven by a fatty acid-binding protein 7-RXRα neurogenic pathway.

Liu R, Choi W, Jain S, Xu X, Elsherbiny M, Glubrecht D Neuro Oncol. 2023; 25(12):2177-2190.

PMID: 37499046 PMC: 10708933. DOI: 10.1093/neuonc/noad134.

FABP4 in obesity-associated carcinogenesis: Novel insights into mechanisms and therapeutic implications.

Liu S, Wu D, Fan Z, Yang J, Li Y, Meng Y Front Mol Biosci. 2022; 9:973955.

PMID: 36060264 PMC: 9438896. DOI: 10.3389/fmolb.2022.973955.

Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism.

Masilamani A, Schulzki R, Yuan S, Haase I, Kling E, Dewes F iScience. 2022; 25(7):104625.

PMID: 35800763 PMC: 9253709. DOI: 10.1016/j.isci.2022.104625.

References
1.
Liang Y, Bollen A, Nicholas M, Gupta N . Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. BMC Clin Pathol. 2005; 5:6. PMC: 1182359. DOI: 10.1186/1472-6890-5-6. View
2.
Houillier C, Lejeune J, Benouaich-Amiel A, Laigle-Donadey F, Criniere E, Mokhtari K . Prognostic impact of molecular markers in a series of 220 primary glioblastomas. Cancer. 2006; 106(10):2218-23. DOI: 10.1002/cncr.21819. View
3.
Anthony T, Mason H, Gridley T, Fishell G, Heintz N . Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev. 2005; 19(9):1028-33. PMC: 1091737. DOI: 10.1101/gad.1302105. View
4.
Haunerland N, Spener F . Fatty acid-binding proteins--insights from genetic manipulations. Prog Lipid Res. 2004; 43(4):328-49. DOI: 10.1016/j.plipres.2004.05.001. View
5.
Liang Y, Bollen A, Aldape K, Gupta N . Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma. BMC Cancer. 2006; 6:97. PMC: 1479358. DOI: 10.1186/1471-2407-6-97. View