Metabolic Heterogeneity and Adaptability in Brain Tumors

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2020 Jun 8

PMID 32506168

Citations 32

Authors

Christian E Badr

Daniel J Silver

Florian A Siebzehnrubl

Loic P Deleyrolle

Affiliations

Soon will be listed here.

Abstract

The metabolic complexity and flexibility commonly observed in brain tumors, especially glioblastoma, is fundamental for their development and progression. The ability of tumor cells to modify their genetic landscape and adapt metabolically, subverts therapeutic efficacy, and inevitably instigates therapeutic resistance. To overcome these challenges and develop effective therapeutic strategies targeting essential metabolic processes, it is necessary to identify the mechanisms underlying heterogeneity and define metabolic preferences and liabilities of malignant cells. In this review, we will discuss metabolic diversity in brain cancer and highlight the role of cancer stem cells in regulating metabolic heterogeneity. We will also highlight potential therapeutic modalities targeting metabolic vulnerabilities and examine how intercellular metabolic signaling can shape the tumor microenvironment.

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