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Correlation of Early Murine Leukemia Virus Titer and H-2 Type with Spontaneous Leukemia in Mice of the BALB/c Times AKR Cross: a Genetic Analysis

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 1975 Apr 1
PMID 165256
Citations 49
Authors
F Lilly
M L DURAN-REYNALS
W P Rowe
Affiliations
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Abstract

Tissue extracts from 6-wk old mice of the AKR strain (H-K) show high levels of infectious murine leukemia virus, and these mice show a near 100% incidence of spontaneous leukemia. In F1 mice of the cross, BALB/c times AKR (H-2K/H-2K), both the occurrence of virus and the incidence of spontaneous leukemia are suppressed to very low values, due largely to the presence of the FV-1b allele inherited from the BALB/c parent. Mice of the (BALB/c times AKR) F-1 times AKR backcross generation were observed for possible correlations between virus expressions at 6 wk of age, H-2 type and leukemia incidence. H-2 type showed at most a weak influence on the occurrence of infectious virus, but there was a very strong correlation between the level of virus expression and the occurrence of leukemia and a strong correlation between H-2 type and leukemia. In addition, there was a highly significant nonrandom distribution of virus-negative mice among the backcross litters, suggesting a maternal effect on virus expression.

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