Selectivity Enhancement of Anion-responsive Electrodes by Pulsed Chronopotentiometry

Overview

Journal Anal Chim Acta

Publisher Elsevier

Specialty Chemistry

Date 2007 Mar 28

PMID 17386545

Citations 10

Authors

Kebede L Gemene

Alexey Shvarev

Eric Bakker

Affiliations

Soon will be listed here.

Abstract

A large and robust selectivity improvement of ion-selective electrodes is presented for the measurement of abundant ions. An improvement in selectivity by more than two orders of magnitude has been attained for the hydrophilic chloride ions measured in a dilute background of the lipophilic ions perchlorate and salicylate in a pulsed chronopotentiometric measurement mode. This is attributed to a robust kinetic discrimination of the dilute lipophilic ions in this measuring mode, which is not possible to achieve in classical potentiometry. Maximum tolerable concentrations of the interfering ions are found to be on the order of 30 microM before causing substantial changes in potential. As an example of practical relevance, the robust detection of chloride in 72 microM salicylate (reflecting 1:10 diluted blood) with a detection limit of 0.5 mM chloride is demonstrated. Corresponding potentiometric sensors did not give a useful chloride response under these conditions.

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