Drosophila Lacking the Cdk5 Activator, P35, Display Defective Axon Guidance, Age-dependent Behavioral Deficits and Reduced Lifespan

Overview

Journal Mech Dev

Publisher Elsevier

Specialties Biology
Cell Biology
Reproductive Medicine

Date 2007 Mar 21

PMID 17368005

Citations 16

Authors

Lisa Connell-Crowley

Duc Vo

Lori Luke

Edward Giniger

Affiliations

Soon will be listed here.

Abstract

The cyclin-dependent kinase Cdk5 has attracted a great deal of attention both because of its roles in cell migration and axon patterning, and the extensive data implicating it in adult-onset neurodegeneration in mammals. Both the kinase activity and the biological effects of Cdk5 are absolutely dependent on association with an activating subunit, called p35. We show here that Drosophila lacking the Cdk5 activator, D-p35, display a wide range of defects in embryonic axon patterning. We further show that, while viable and fertile, p35 mutant adults display progressive, age-dependent loss of motor function and have a significantly shortened lifespan.

Citing Articles

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PMID: 39292114 PMC: 11552616. DOI: 10.1242/bio.060515.

Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration in Drosophila.

Wodrich A, Harris B, Giniger E Biol Open. 2024; 13(7).

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MANIPULATING MITOCHONDRIAL REACTIVE OXYGEN SPECIES ALTERS SURVIVAL IN UNEXPECTED WAYS IN A MODEL OF NEURODEGENERATION.

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Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration in .

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