» Articles » PMID: 17367499

Human Mesenchymal Stem Cells in Contact with Their Environment: Surface Characteristics and the Integrin System

Overview
Journal J Cell Mol Med
Date 2007 Mar 21
PMID 17367499
Citations 109
Authors
Affiliations
Soon will be listed here.
Abstract

The identification of mesenchymal stem cells (MSCs) in adult human tissues and the disclosure of their self-renew-al and multi-lineage differentiation capabilities have provided exciting prospects for cell-based regeneration and tis-sue engineering. Although a considerable amount of data is available describing MSCs, there is still lack of information regarding the molecular mechanisms that govern their adhesion and migration. In this work, we will review the current state of knowledge on integrins and other adhesion molecules found to be expressed on MSCs. The discussed topics include the characteristics of MSCs and their clinical applications, integrins and their central role in cell-matrix attachment and migration, and comments on mobilization, differentiation and contribution to tumour development. Finally, by understanding the complex and fundamental pathways by which MSCs attach and migrate, it might be possible to fine-tune the strategies for effective and safe use of MSCs in regenerative therapies.

Citing Articles

Improving the Wound Healing Process: Pivotal role of Mesenchymal stromal/stem Cells and Immune Cells.

Sadeghi M, Moghaddam A, Amiri A, Charoghdoozi K, Mohammadi M, Dehnavi S Stem Cell Rev Rep. 2025; .

PMID: 39921839 DOI: 10.1007/s12015-025-10849-0.


The clinical potential of meniscal progenitor cells.

Yan W, Wang J, Fan P, Roberts S, Wright K, Zhang Z J Cartil Jt Preserv. 2024; 4(4):None.

PMID: 39669533 PMC: 11636529. DOI: 10.1016/j.jcjp.2024.100166.


Impact of mesenchymal stem cell size and adhesion modulation on in vivo distribution: insights from quantitative PET imaging.

Ji X, Wang L, Zhong Y, Xu Q, Yan J, Pan D Stem Cell Res Ther. 2024; 15(1):456.

PMID: 39609885 PMC: 11606219. DOI: 10.1186/s13287-024-04078-4.


Classes of Stem Cells: From Biology to Engineering.

Shah S, Ghosh D, Otsuka T, Laurencin C Regen Eng Transl Med. 2024; 10(3):309-322.

PMID: 39387056 PMC: 11463971. DOI: 10.1007/s40883-023-00317-x.


Adipose-Derived Stem-Cell-Membrane-Coated PLGA-PEI Nanoparticles Promote Wound Healing via Efficient Delivery of miR-21.

Peng H, Du F, Wang J, Wu Y, Wei Q, Chen A Pharmaceutics. 2024; 16(9).

PMID: 39339150 PMC: 11434648. DOI: 10.3390/pharmaceutics16091113.


References
1.
Chastain S, Kundu A, Dhar S, Calvert J, Putnam A . Adhesion of mesenchymal stem cells to polymer scaffolds occurs via distinct ECM ligands and controls their osteogenic differentiation. J Biomed Mater Res A. 2006; 78(1):73-85. DOI: 10.1002/jbm.a.30686. View

2.
Cukierman E, Pankov R, Stevens D, Yamada K . Taking cell-matrix adhesions to the third dimension. Science. 2001; 294(5547):1708-12. DOI: 10.1126/science.1064829. View

3.
Gronthos S, Simmons P, Graves S, Robey P . Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix. Bone. 2001; 28(2):174-81. DOI: 10.1016/s8756-3282(00)00424-5. View

4.
Foster L, Zeemann P, Li C, Mann M, Jensen O, Kassem M . Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Stem Cells. 2005; 23(9):1367-77. DOI: 10.1634/stemcells.2004-0372. View

5.
Kern S, Eichler H, Stoeve J, Kluter H, Bieback K . Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006; 24(5):1294-301. DOI: 10.1634/stemcells.2005-0342. View