Human Mesenchymal Stem Cells in Contact with Their Environment: Surface Characteristics and the Integrin System

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2007 Mar 21

PMID 17367499

Citations 109

Authors

Denitsa Docheva

Cvetan Popov

Wolf Mutschler

Matthias Schieker

Affiliations

Soon will be listed here.

Abstract

The identification of mesenchymal stem cells (MSCs) in adult human tissues and the disclosure of their self-renew-al and multi-lineage differentiation capabilities have provided exciting prospects for cell-based regeneration and tis-sue engineering. Although a considerable amount of data is available describing MSCs, there is still lack of information regarding the molecular mechanisms that govern their adhesion and migration. In this work, we will review the current state of knowledge on integrins and other adhesion molecules found to be expressed on MSCs. The discussed topics include the characteristics of MSCs and their clinical applications, integrins and their central role in cell-matrix attachment and migration, and comments on mobilization, differentiation and contribution to tumour development. Finally, by understanding the complex and fundamental pathways by which MSCs attach and migrate, it might be possible to fine-tune the strategies for effective and safe use of MSCs in regenerative therapies.

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