Switching on Reparative Angiogenesis: Essential Role of the Vascular Erythropoietin Receptor

Overview

Journal Circ Res

Specialty Cardiology & Vascular Diseases

Date 2007 Mar 17

PMID 17363704

Citations 2

Authors

Paolo Madeddu

Costanza Emanueli

Affiliations

Soon will be listed here.

Citing Articles

EPO receptor gain-of-function causes hereditary polycythemia, alters CD34 cell differentiation and increases circulating endothelial precursors.

Perrotta S, Cucciolla V, Ferraro M, Ronzoni L, Tramontano A, Rossi F PLoS One. 2010; 5(8):e12015.

PMID: 20700488 PMC: 2916842. DOI: 10.1371/journal.pone.0012015.

Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart.

Carraway M, Suliman H, Jones W, Chen C, Babiker A, Piantadosi C Circ Res. 2010; 106(11):1722-30.

PMID: 20395592 PMC: 2895561. DOI: 10.1161/CIRCRESAHA.109.214353.

References

Peichev M, Naiyer A, Pereira D, Zhu Z, Lane W, Williams M . Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood. 2000; 95(3):952-8. View

Madeddu P, Emanueli C, Pelosi E, Salis M, Cerio A, Bonanno G . Transplantation of low dose CD34+KDR+ cells promotes vascular and muscular regeneration in ischemic limbs. FASEB J. 2004; 18(14):1737-9. DOI: 10.1096/fj.04-2192fje. View

Satoh K, Kagaya Y, Nakano M, Ito Y, Ohta J, Tada H . Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. Circulation. 2006; 113(11):1442-50. DOI: 10.1161/CIRCULATIONAHA.105.583732. View

Nakano M, Satoh K, Fukumoto Y, Ito Y, Kagaya Y, Ishii N . Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice. Circ Res. 2007; 100(5):662-9. DOI: 10.1161/01.RES.0000260179.43672.fe. View

Heeschen C, Aicher A, Lehmann R, Fichtlscherer S, Vasa M, Urbich C . Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. Blood. 2003; 102(4):1340-6. DOI: 10.1182/blood-2003-01-0223. View

Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T . Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997; 275(5302):964-7. DOI: 10.1126/science.275.5302.964. View

Anagnostou A, Liu Z, Steiner M, Chin K, Lee E, Kessimian N . Erythropoietin receptor mRNA expression in human endothelial cells. Proc Natl Acad Sci U S A. 1994; 91(9):3974-8. PMC: 43705. DOI: 10.1073/pnas.91.9.3974. View

Ziegler B, Valtieri M, Porada G, De Maria R, Muller R, Masella B . KDR receptor: a key marker defining hematopoietic stem cells. Science. 1999; 285(5433):1553-8. DOI: 10.1126/science.285.5433.1553. View

Tam B, Wei K, Rudge J, Hoffman J, Holash J, Park S . VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med. 2006; 12(7):793-800. DOI: 10.1038/nm1428. View

10.

Suzuki N, Ohneda O, Takahashi S, Higuchi M, Mukai H, Nakahata T . Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality. Blood. 2002; 100(7):2279-88. DOI: 10.1182/blood-2002-01-0124. View

11.

Pelosi E, Valtieri M, Coppola S, Botta R, Gabbianelli M, Lulli V . Identification of the hemangioblast in postnatal life. Blood. 2002; 100(9):3203-8. DOI: 10.1182/blood-2002-05-1511. View

12.

Semenza G, Wang G . A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol. 1992; 12(12):5447-54. PMC: 360482. DOI: 10.1128/mcb.12.12.5447-5454.1992. View

13.

Wu H, Lee S, Gao J, Liu X, Iruela-Arispe M . Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development. 1999; 126(16):3597-605. DOI: 10.1242/dev.126.16.3597. View

14.

Anagnostou A, Lee E, Kessimian N, Levinson R, Steiner M . Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. Proc Natl Acad Sci U S A. 1990; 87(15):5978-82. PMC: 54453. DOI: 10.1073/pnas.87.15.5978. View

15.

Stockmann C, Fandrey J . Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression. Clin Exp Pharmacol Physiol. 2006; 33(10):968-79. DOI: 10.1111/j.1440-1681.2006.04474.x. View

16.

Urao N, Okigaki M, Yamada H, Aadachi Y, Matsuno K, Matsui A . Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia. Circ Res. 2006; 98(11):1405-13. DOI: 10.1161/01.RES.0000224117.59417.f3. View

17.

Wu H, Klingmuller U, Besmer P, Lodish H . Interaction of the erythropoietin and stem-cell-factor receptors. Nature. 1995; 377(6546):242-6. DOI: 10.1038/377242a0. View

18.

Constantinescu , Ghaffari , Lodish . The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction. Trends Endocrinol Metab. 1999; 10(1):18-23. DOI: 10.1016/s1043-2760(98)00101-5. View

19.

Crivellato E, Nico B, Vacca A, Djonov V, Presta M, Ribatti D . Recombinant human erythropoietin induces intussusceptive microvascular growth in vivo. Leukemia. 2003; 18(2):331-6. DOI: 10.1038/sj.leu.2403246. View

20.

Krantz S . Erythropoietin. Blood. 1991; 77(3):419-34. View