Genetics of Focal Segmental Glomerulosclerosis

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2007 Mar 10

PMID 17347836

Citations 12

Authors

Robert P Woroniecki

Jeffrey B Kopp

Affiliations

Soon will be listed here.

Abstract

The recent advances in understanding the pathophysiology of focal segmental glomerulosclerosis (FSGS) and molecular function of glomerular filtration barrier come directly from genetic linkage and positional cloning studies. The exact role and function of the newly discovered genes and proteins are being investigated by in vitro and in vivo mechanistic studies. Those genes and proteins interactions seem to change susceptibility to kidney disease progression. Better understanding of their exact role in the development of FSGS may influence future therapies and outcomes in this complex disease.

Citing Articles

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Podocyte Foot Process Effacement Precedes Albuminuria and Glomerular Hypertrophy in CD2-Associated Protein Deficient Mice.

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