Dose Dependence and Therapeutic Window for the Neuroprotective Effects of 17beta-estradiol when Administered After Cerebral Ischemia

Overview

Journal Neurosci Lett

Specialty Neurology

Date 2007 Mar 3

PMID 17331646

Citations 24

Authors

Ran Liu

Xiaofei Wang

Qing Liu

Shao-Hua Yang

James W Simpkins

Affiliations

Soon will be listed here.

Abstract

The present study was undertaken to determine if the neuroprotective effect of 17beta-estradiol (E(2)) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E(2) at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E(2) extended the therapeutic window to 6h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window.

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