Endothelial Cells Derived from Human Embryonic Stem Cells Form Durable Blood Vessels in Vivo

Overview

Journal Nat Biotechnol

Specialty Biotechnology

Date 2007 Feb 27

PMID 17322871

Citations 127

Authors

Zack Z Wang

Patrick Au

Tong Chen

Ying Shao

Laurence M Daheron

Hao Bai

Melanie Arzigian

Dai Fukumura

Rakesh K Jain

David T Scadden

Affiliations

Soon will be listed here.

Abstract

We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.

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