Cytogenetic Study in Cases with Recurrent Abortion in Saudi Arabia

Overview

Journal Ann Saudi Med

Specialty General Medicine

Date 2007 Feb 27

PMID 17322664

Citations 13

Authors

M Al-Hussain

L Al-Nuaim

Z Abu Talib

O K Zaki

Affiliations

Soon will be listed here.

Abstract

Background: A proportion of cases with repeated abortion are caused by chromosomal abnormality in one of the parents. Several studies have been done to determine the role of chromosomal abnormalities in couples with repeated fetal loss in various countries. None of these studies was done in the Arab Peninsula.

Material And Methods: Cytogenetic study was done for 193 consecutive Saudi couples who presented with repeated abortion at the King Khalid University Hospital in Riyadh, Saudi Arabia.

Results: We found that the frequency of chromosomal abnormalities was not significantly different from that reported worldwide. The nature of those abnormalities and their relation to the obstetric history of cases were discussed.

Conclusion: This study should help physicians working in the region to realize the contribution of chromosomal abnormalities to cases of repeated fetal loss. It should also help in setting priorities of cytogenetic screening in individual cases.

Citing Articles

High incidences of chromosomal aberrations and Y chromosome micro-deletions as prominent causes for recurrent pregnancy losses in highly ethnic and consanguineous population.

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PMID: 34542677 DOI: 10.1007/s00404-021-06235-z.

Chromosomal abnormalities in couples with recurrent spontaneous miscarriage: a 21-year retrospective study, a report of a novel insertion, and a literature review.

Elkarhat Z, Kindil Z, Zarouf L, Razoki L, Aboulfaraj J, Elbakay C J Assist Reprod Genet. 2018; 36(3):499-507.

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Description of cytogenetic abnormalities and the pregnancy outcomes of couples with recurrent pregnancy loss in a tertiary-care center in Saudi Arabia.

Awartani K, Al Shabibi M Saudi Med J. 2018; 39(3):239-242.

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A report of nine cases and review of the literature of infertile men carrying balanced translocations involving chromosome 5.

Zhang H, Wang R, Pan Y, Zhang H, Li L, Zhu H Mol Cytogenet. 2018; 11:10.

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Clinical features of carriers of reciprocal chromosomal translocations involving chromosome 2: report of nine cases and review of the literature.

Zhang X, Zhang H, Hu C, Wang R, Xi Q, Liu R Int Braz J Urol. 2017; 44(4):785-793.

PMID: 29219278 PMC: 6092653. DOI: 10.1590/S1677-5538.IBJU.2017.0233.