Length Variation of DC-SIGN and L-SIGN Neck-region Has No Impact on Tuberculosis Susceptibility

Overview

Journal Hum Immunol

Specialty Allergy & Immunology

Date 2007 Feb 27

PMID 17321900

Citations 13

Authors

Luis B Barreiro

Olivier Neyrolles

Chantal L Babb

Paul D van Helden

Brigitte Gicquel

Eileen G Hoal

Lluis Quintana-Murci

Affiliations

Soon will be listed here.

Abstract

The C-type lectins DC-SIGN and L-SIGN are important pathogen-recognition receptors of the human innate immune system. Both lectins have been shown to interact with a vast range of infectious agents, including Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. In addition, DC-SIGN and L-SIGN possess a neck region, made up of a variable number of 23 amino acid tandem repeats, which plays a crucial role in the tetramerization of these proteins and support of the carbohydrate recognition domain. The length of the neck region, which shows variable levels of polymorphism, can critically influence the pathogen binding properties of these two receptors. We therefore investigated the impact of the DC-SIGN and L-SIGN neck-region length variation on the outcome of tuberculosis by screening this polymorphism in a large cohort of Coloured South African origin. The analyses of 711 individuals, including 351 tuberculosis patients and 360 healthy controls, revealed that none of the DC-SIGN and L-SIGN neck-region variants or genotypes seems to influence the individual susceptibility to develop tuberculosis.

Citing Articles

Relationship between the Number of Repeats in the Neck Regions of L-SIGN and Augmented Virus Replication and Immune Responses in Dengue Hemorrhagic Fever.

Liu K, Chen P, Wang L, Lee I, Yang K, Chen R Int J Mol Sci. 2024; 25(10).

PMID: 38791534 PMC: 11122574. DOI: 10.3390/ijms25105497.

C-type lectin receptors in tuberculosis: what we know.

Goyal S, Klassert T, Slevogt H Med Microbiol Immunol. 2016; 205(6):513-535.

PMID: 27469378 DOI: 10.1007/s00430-016-0470-1.

The association between CD209 gene polymorphisms and pulmonary tuberculosis susceptibility: a meta-analysis.

Yi L, Zhang K, Mo Y, Zhen G, Zhao J Int J Clin Exp Pathol. 2016; 8(10):12437-45.

PMID: 26722430 PMC: 4680375.

Association of CD209 and CD209L polymorphisms with tuberculosis infection in a Northeastern Brazilian population.

Silva R, Segat L, da Cruz H, Schindler H, Montenegro L, Crovella S Mol Biol Rep. 2014; 41(8):5449-57.

PMID: 24874302 DOI: 10.1007/s11033-014-3416-y.

A panel of ancestry informative markers for the complex five-way admixed South African coloured population.

Daya M, van der Merwe L, Galal U, Moller M, Salie M, Chimusa E PLoS One. 2013; 8(12):e82224.

PMID: 24376522 PMC: 3869660. DOI: 10.1371/journal.pone.0082224.

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