Microenvironment of the Involuting Mammary Gland Mediates Mammary Cancer Progression

Overview

Journal J Mammary Gland Biol Neoplasia

Date 2007 Feb 24

PMID 17318269

Citations 97

Authors

Pepper Schedin

Jenean OBrien

Michael Rudolph

Torsten Stein

Virginia Borges

Affiliations

Soon will be listed here.

Abstract

Breast cancer diagnosed after a completed pregnancy has higher metastatic potential and therefore a much poorer prognosis. We hypothesize that following pregnancy the process of mammary gland involution, which returns the gland to its pre-pregnant state, co-opts some of the programs of wound healing. The pro-inflammatory milieu that results, while physiologically normal, promotes tumor progression. In this review, the similarities between mammary gland involution after cessation of milk-production and pathological tissue remodeling are discussed in light of emerging data demonstrating a role for pathological tissue remodeling in cancer.

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