A Developmental Atlas of Rat Mammary Gland Histology

Overview

Journal J Mammary Gland Biol Neoplasia

Date 2001 Jan 10

PMID 11149571

Citations 40

Authors

K M Darcy

M M Ip

Affiliations

Soon will be listed here.

Abstract

The mammary gland is a dynamic tissue that undergoes epithelial expansion and invasion during puberty and cycles of branching and lobular morphogenesis, secretory differentiation, and regression during pregnancy, lactation, and involution. The alteration in the mammary gland epithelium during its postnatal differentiation is accompanied by changes in the multiple stromal cell types present in this complex tissue. The postnatal plasticity of the epithelium, endothelium, and stromal cells of the mammary gland may contribute to its susceptibility to carcinogenesis. The purpose of this review is to assist researchers in recognizing histological changes in the epithelium and stroma of the rat mammary gland throughout development.

Citing Articles

A xenotransplantation mouse model to study physiology of the mammary gland from large mammals.

Miller J, Reddy A, Harman R, Van de Walle G PLoS One. 2024; 19(2):e0298390.

PMID: 38416747 PMC: 10901318. DOI: 10.1371/journal.pone.0298390.

Thermosensitive Polymeric Nanoparticles for Drug Co-Encapsulation and Breast Cancer Treatment.

Dartora V, Passos J, Costa-Lotufo L, Lopes L, Panitch A Pharmaceutics. 2024; 16(2).

PMID: 38399285 PMC: 10892816. DOI: 10.3390/pharmaceutics16020231.

Modeling Mammary Organogenesis from Biological First Principles: A Systems Biology Approach.

Schaeberle C, Bouffard V, Sonnenschein C, Soto A Methods Mol Biol. 2023; 2745:177-188.

PMID: 38060186 DOI: 10.1007/978-1-0716-3577-3_11.

Mammary Glands of Women, Female Dogs and Female Rats: Similarities and Differences to Be Considered in Breast Cancer Research.

Ferreira T, Gama A, Seixas F, Faustino-Rocha A, Lopes C, Gaspar V Vet Sci. 2023; 10(6).

PMID: 37368765 PMC: 10303014. DOI: 10.3390/vetsci10060379.

Advances in Immunocompetent Mouse and Rat Models.

Bu W, Li Y Cold Spring Harb Perspect Med. 2023; 14(3.

PMID: 37217281 PMC: 10810718. DOI: 10.1101/cshperspect.a041328.

References

Tucker H, REECE R . Nucleic acid content of mammary glands of lactating rats. Proc Soc Exp Biol Med. 1963; 112:409-12. DOI: 10.3181/00379727-112-28060. View

Emerman J, Vogl A . Cell size and shape changes in the myoepithelium of the mammary gland during differentiation. Anat Rec. 1986; 216(3):405-15. DOI: 10.1002/ar.1092160310. View

Silberstein G, Strickland P, Coleman S, DANIEL C . Epithelium-dependent extracellular matrix synthesis in transforming growth factor-beta 1-growth-inhibited mouse mammary gland. J Cell Biol. 1990; 110(6):2209-19. PMC: 2116118. DOI: 10.1083/jcb.110.6.2209. View

Joshi K, Smith J, Perusinghe N, Monoghan P . Cell proliferation in the human mammary epithelium. Differential contribution by epithelial and myoepithelial cells. Am J Pathol. 1986; 124(2):199-206. PMC: 1888284. View

Richardson K . Contractile tissues in the mammary gland, with special reference to myoepithelium in the goat. Proc R Soc Lond B Biol Sci. 1949; 136(882):30-45. DOI: 10.1098/rspb.1949.0004. View

DULBECCO R, Unger M, Armstrong B, Bowman M, Syka P . Epithelial cell types and their evolution in the rat mammary gland determined by immunological markers. Proc Natl Acad Sci U S A. 1983; 80(4):1033-7. PMC: 393522. DOI: 10.1073/pnas.80.4.1033. View

Tucker H, REECE R . Nucleic acid content of mammary glands of pregnant rats. Proc Soc Exp Biol Med. 1963; 112:370-2. DOI: 10.3181/00379727-112-28048. View

Russo J, Russo I . DNA labeling index and structure of the rat mammary gland as determinants of its susceptibility to carcinogenesis. J Natl Cancer Inst. 1978; 61(6):1451-9. View

Gordon J, BERNFIELD M . The basal lamina of the postnatal mammary epithelium contains glycosaminoglycans in a precise ultrastructural organization. Dev Biol. 1980; 74(1):118-35. DOI: 10.1016/0012-1606(80)90056-1. View

10.

Marti A, Jehn B, Costello E, Keon N, Ke G, Martin F . Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells. Oncogene. 1994; 9(4):1213-23. View

11.

Russo J, Tay L, Russo I . Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat. 1982; 2(1):5-73. DOI: 10.1007/BF01805718. View

12.

Silberstein G, DANIEL C . Elvax 40P implants: sustained, local release of bioactive molecules influencing mammary ductal development. Dev Biol. 1982; 93(1):272-8. DOI: 10.1016/0012-1606(82)90259-7. View

13.

Russo I, Russo J . Developmental stage of the rat mammary gland as determinant of its susceptibility to 7,12-dimethylbenz[a]anthracene. J Natl Cancer Inst. 1978; 61(6):1439-49. View

14.

Russo J, Gusterson B, Rogers A, Russo I, WELLINGS S, van Zwieten M . Comparative study of human and rat mammary tumorigenesis. Lab Invest. 1990; 62(3):244-78. View

15.

RICHARDS R, BENSON G . Involvement of the macrophage system in the involution of the mammary gland in the albino rat. J Endocrinol. 1971; 51(1):149-56. DOI: 10.1677/joe.0.0510149. View

16.

GRIFFITH D, Turner C . Normal and experimental involution of rat mammary gland. Proc Soc Exp Biol Med. 1961; 107:668-70. DOI: 10.3181/00379727-107-26722. View

17.

Silberstein G, Flanders K, Roberts A, DANIEL C . Regulation of mammary morphogenesis: evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-beta 1. Dev Biol. 1992; 152(2):354-62. DOI: 10.1016/0012-1606(92)90142-4. View

18.

Hovey R, McFadden T, Akers R . Regulation of mammary gland growth and morphogenesis by the mammary fat pad: a species comparison. J Mammary Gland Biol Neoplasia. 1999; 4(1):53-68. DOI: 10.1023/a:1018704603426. View

19.

Marti A, Feng Z, Altermatt H, Jaggi R . Milk accumulation triggers apoptosis of mammary epithelial cells. Eur J Cell Biol. 1997; 73(2):158-65. View

20.

Brown N, Lamartiniere C . Xenoestrogens alter mammary gland differentiation and cell proliferation in the rat. Environ Health Perspect. 1995; 103(7-8):708-13. PMC: 1522196. DOI: 10.1289/ehp.95103708. View