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Optimization of Halopemide for Phospholipase D2 Inhibition

Overview
Specialty Biochemistry
Date 2007 Feb 24
PMID 17317170
Citations 57
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Abstract

Halopemide, which was identified by HTS to inhibit phospholipase D2 (PLD2), provided the basis for an exploratory effort to identify potent inhibitors of PLD2 for use as inflammatory mediators. Parallel synthesis and purification were utilized to rapidly identify orally available amide analogs derived from indole 2-carboxylic acids with superior potency versus PLD2.

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