Mesenchymal Stromal Cells. Biology of Adult Mesenchymal Stem Cells: Regulation of Niche, Self-renewal and Differentiation

Overview

Journal Arthritis Res Ther

Publisher Biomed Central

Specialty Rheumatology

Date 2007 Feb 24

PMID 17316462

Citations 363

Authors

Catherine M Kolf

Elizabeth Cho

Rocky S Tuan

Affiliations

Soon will be listed here.

Abstract

Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition we review recent research on the concept of stem cell niche, and its relevance to adult mesenchymal stem cells.

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References

Abecassis L, Rogier E, Vazquez A, Atfi A, Bourgeade M . Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways. J Biol Chem. 2004; 279(29):30474-9. DOI: 10.1074/jbc.M403294200. View

Etheridge S, Spencer G, Heath D, Genever P . Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells. Stem Cells. 2004; 22(5):849-60. DOI: 10.1634/stemcells.22-5-849. View

Gaspar C, Fodde R . APC dosage effects in tumorigenesis and stem cell differentiation. Int J Dev Biol. 2004; 48(5-6):377-86. DOI: 10.1387/ijdb.041807cg. View

Datta N, Holtorf H, Sikavitsas V, Jansen J, Mikos A . Effect of bone extracellular matrix synthesized in vitro on the osteoblastic differentiation of marrow stromal cells. Biomaterials. 2004; 26(9):971-7. DOI: 10.1016/j.biomaterials.2004.04.001. View

Santa Maria L, Rojas C, Minguell J . Signals from damaged but not undamaged skeletal muscle induce myogenic differentiation of rat bone-marrow-derived mesenchymal stem cells. Exp Cell Res. 2004; 300(2):418-26. DOI: 10.1016/j.yexcr.2004.07.017. View

Baksh D, Song L, Tuan R . Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med. 2004; 8(3):301-16. PMC: 6740223. DOI: 10.1111/j.1582-4934.2004.tb00320.x. View

FRIEDENSTEIN A, Chailakhjan R, LALYKINA K . The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970; 3(4):393-403. DOI: 10.1111/j.1365-2184.1970.tb00347.x. View

Schofield R . The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells. 1978; 4(1-2):7-25. View

Simmons P, Torok-Storb B . Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood. 1991; 78(1):55-62. View

10.

Haynesworth S, Baber M, Caplan A . Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone. 1992; 13(1):69-80. DOI: 10.1016/8756-3282(92)90363-2. View

11.

Wolfman N, Hattersley G, Cox K, Celeste A, Nelson R, Yamaji N . Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest. 1997; 100(2):321-30. PMC: 508194. DOI: 10.1172/JCI119537. View

12.

Kengaku M, Capdevila J, De La Pena J, Johnson R, Izpisua Belmonte J, Tabin C . Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science. 1998; 280(5367):1274-7. DOI: 10.1126/science.280.5367.1274. View

13.

Schwartz J, Van de Pavert S, Clarke I, Rao A, Ray D, Vrana K . Paracrine interactions within the pituitary gland. Ann N Y Acad Sci. 1998; 839:239-43. DOI: 10.1111/j.1749-6632.1998.tb10767.x. View

14.

Pittenger M, Mackay A, Beck S, Jaiswal R, Douglas R, Mosca J . Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284(5411):143-7. DOI: 10.1126/science.284.5411.143. View

15.

Doherty M, Canfield A . Gene expression during vascular pericyte differentiation. Crit Rev Eukaryot Gene Expr. 1999; 9(1):1-17. View

16.

Brown D, Wagner D, Li X, Richardson J, Olson E . Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis. Development. 1999; 126(19):4317-29. DOI: 10.1242/dev.126.19.4317. View

17.

Kleber M, Sommer L . Wnt signaling and the regulation of stem cell function. Curr Opin Cell Biol. 2004; 16(6):681-7. DOI: 10.1016/j.ceb.2004.08.006. View

18.

Boland G, Perkins G, Hall D, Tuan R . Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cell Biochem. 2004; 93(6):1210-30. DOI: 10.1002/jcb.20284. View

19.

Ringrose L, Paro R . Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet. 2004; 38:413-43. DOI: 10.1146/annurev.genet.38.072902.091907. View

20.

Chen D, Zhao M, Mundy G . Bone morphogenetic proteins. Growth Factors. 2004; 22(4):233-41. DOI: 10.1080/08977190412331279890. View