Unlocking the Versatile Potential: Adipose-derived Mesenchymal Stem Cells in Ocular Surface Reconstruction and Oculoplastics

Overview

Journal World J Stem Cells

Publisher Baishideng Publishing Group

Date 2024 Mar 8

PMID 38455097

Authors

Pier Luigi Surico

Anna Scarabosio

Giovanni Miotti

Martina Grando

Carlo Salati

Pier Camillo Parodi

Leopoldo Spadea

Marco Zeppieri

Affiliations

Soon will be listed here.

Abstract

This review comprehensively explores the versatile potential of mesenchymal stem cells (MSCs) with a specific focus on adipose-derived MSCs. Ophthalmic and oculoplastic surgery, encompassing diverse procedures for ocular and periocular enhancement, demands advanced solutions for tissue restoration, functional and aesthetic refinement, and aging. Investigating immunomodulatory, regenerative, and healing capacities of MSCs, this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside, addressing common unmet needs in the field of reconstructive and regenerative surgery.

Citing Articles

Advancements and challenges in stem cell transplantation for regenerative medicine.

Wei L, Yan W, Shah W, Zhang Z, Wang M, Liu B Heliyon. 2024; 10(16):e35836.

PMID: 39247380 PMC: 11379611. DOI: 10.1016/j.heliyon.2024.e35836.

Whole-eye transplantation: Current challenges and future perspectives.

Scarabosio A, Surico P, Tereshenko V, Singh R, Salati C, Spadea L World J Transplant. 2024; 14(2):95009.

PMID: 38947970 PMC: 11212585. DOI: 10.5500/wjt.v14.i2.95009.

References

Pittenger M, Mackay A, Beck S, Jaiswal R, Douglas R, Mosca J . Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284(5411):143-7. DOI: 10.1126/science.284.5411.143. View

Shu D, Lovicu F . Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis. Prog Retin Eye Res. 2017; 60:44-65. PMC: 5600870. DOI: 10.1016/j.preteyeres.2017.08.001. View

Yin J . Advances in corneal graft rejection. Curr Opin Ophthalmol. 2021; 32(4):331-337. PMC: 9290782. DOI: 10.1097/ICU.0000000000000767. View

Martinez-Conesa E, Espel E, Reina M, Casaroli-Marano R . Characterization of ocular surface epithelial and progenitor cell markers in human adipose stromal cells derived from lipoaspirates. Invest Ophthalmol Vis Sci. 2011; 53(1):513-20. PMC: 3292382. DOI: 10.1167/iovs.11-7550. View

Weyand B, Vogt P . Potential of mesenchymal stem cell applications in plastic and reconstructive surgery. Adv Biochem Eng Biotechnol. 2012; 130:55-67. DOI: 10.1007/10_2012_162. View

Wang Y, Pan J, Wang D, Liu J . The Use of Stem Cells in Neural Regeneration: A Review of Current Opinion. Curr Stem Cell Res Ther. 2018; 13(7):608-617. DOI: 10.2174/1574888X13666180720100738. View

Yan Y, Zhou Y, Zhang S, Cui C, Song X, Zhu X . Impact of Full-Incision Double-Eyelid Blepharoplasty on Tear Film Dynamics and Dry Eye Symptoms in Young Asian Females. Aesthetic Plast Surg. 2020; 44(6):2109-2116. DOI: 10.1007/s00266-020-01874-0. View

Nieto-Nicolau N, Martinez-Conesa E, Fuentes-Julian S, Arnalich-Montiel F, Garcia-Tunon I, De Miguel M . Priming human adipose-derived mesenchymal stem cells for corneal surface regeneration. J Cell Mol Med. 2021; 25(11):5124-5137. PMC: 8178265. DOI: 10.1111/jcmm.16501. View

Zoumalan C, Roostaeian J . Simplifying Blepharoplasty. Plast Reconstr Surg. 2015; 137(1):196e-213e. DOI: 10.1097/PRS.0000000000001906. View

10.

Lee M, Ko A, Ko J, Lee H, Kim M, Wee W . Mesenchymal stem/stromal cells protect the ocular surface by suppressing inflammation in an experimental dry eye. Mol Ther. 2014; 23(1):139-46. PMC: 4426793. DOI: 10.1038/mt.2014.159. View

11.

Bandeira F, Goh T, Setiawan M, Yam G, Mehta J . Cellular therapy of corneal epithelial defect by adipose mesenchymal stem cell-derived epithelial progenitors. Stem Cell Res Ther. 2020; 11(1):14. PMC: 6942321. DOI: 10.1186/s13287-019-1533-1. View

12.

Huang Y, Wu Q, Tam P . Immunomodulatory Mechanisms of Mesenchymal Stem Cells and Their Potential Clinical Applications. Int J Mol Sci. 2022; 23(17). PMC: 9456387. DOI: 10.3390/ijms231710023. View

13.

Kosaric N, Kiwanuka H, Gurtner G . Stem cell therapies for wound healing. Expert Opin Biol Ther. 2019; 19(6):575-585. DOI: 10.1080/14712598.2019.1596257. View

14.

Benslimane F, Cintra H . 15 Years of Upper Eyelid Micro-fat Graft: the Good, the Bad and the Ugly. Aesthetic Plast Surg. 2020; 45(3):1035-1046. DOI: 10.1007/s00266-020-01946-1. View

15.

Yin J, Jurkunas U . Limbal Stem Cell Transplantation and Complications. Semin Ophthalmol. 2017; 33(1):134-141. DOI: 10.1080/08820538.2017.1353834. View

16.

Alves M, Asbell P, Dogru M, Giannaccare G, Grau A, Gregory D . TFOS Lifestyle Report: Impact of environmental conditions on the ocular surface. Ocul Surf. 2023; 29:1-52. DOI: 10.1016/j.jtos.2023.04.007. View

17.

Cho Y, Song H, Bhang S, Lee S, Kang B, Lee J . Therapeutic effects of human adipose stem cell-conditioned medium on stroke. J Neurosci Res. 2012; 90(9):1794-802. DOI: 10.1002/jnr.23063. View

18.

Eleuteri S, Fierabracci A . Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications. Int J Mol Sci. 2019; 20(18). PMC: 6770239. DOI: 10.3390/ijms20184597. View

19.

Said D, Dua H . Chemical burns acid or alkali, what's the difference?. Eye (Lond). 2019; 34(8):1299-1300. PMC: 7376166. DOI: 10.1038/s41433-019-0735-1. View

20.

Di Zazzo A, Coassin M, Surico P, Bonini S . Age-related ocular surface failure: A narrative review. Exp Eye Res. 2022; 219:109035. DOI: 10.1016/j.exer.2022.109035. View