Neuroprotective Effects of Kobophenol A Against the Withdrawal of Tropic Support, Nitrosative Stress, and Mitochondrial Damage in SH-SY5Y Neuroblastoma Cells

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2007 Feb 16

PMID 17300930

Citations 7

Authors

Sung Ryul Lee

Jong Hwan Kwak

Hyoung Ja Kim

Suhkneung Pyo

Affiliations

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Abstract

This study examined the neuroprotective effects of kobophenol A (kob A), oligomeric stillbene, and a resveratrol tetramer. Neuronal death induced by the withdrawal of tropic support was ameliorated by kob A. The protective effect of kob A against nitrosative/oxidative or mitochondrial damages resulted in the inhibition of the ROS, intracellular calcium ion level, and mitochondrial transmembrane potential changes on SH-SY5Y cells.

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