Alpha 2.0
Login Register
» Articles » PMID: 17273552

Transcriptional Regulation of Epithelial-mesenchymal Transition

Overview
Journal J Clin Invest
Specialty General Medicine
Date 2007 Feb 3
PMID 17273552
Citations 19
Authors
Yingqi Teng
Michael Zeisberg
Raghu Kalluri
Affiliations
Soon will be listed here.
Abstract

It has become increasingly obvious that the notion of a terminally differentiated cell is likely a simplified concept. Epithelial-mesenchymal transition (EMT), during which epithelial cells assume a mesenchymal phenotype, is a key event occurring during normal development and pathological processes. Multiple extracellular stimuli and transcriptional regulators can trigger EMT, but how such distinct signaling pathways orchestrate the complex cellular events that facilitate EMT is not well understood. In this issue of the JCI, Venkov et al. report on their examination of fibroblasts resulting from EMT and describe a novel protein-DNA complex that is essential for transcription of fibroblast-specific protein 1 (FSP1) and sufficient to induce early EMT events (see the related article beginning on page 482). Collectively, their results suggest that this complex is an important regulator of the EMT transcriptome.

Citing Articles

Population dynamics of EMT elucidates the timing and distribution of phenotypic intra-tumoral heterogeneity.

Najafi A, Jolly M, George J iScience. 2023; 26(7):106964.

PMID: 37426354 PMC: 10329148. DOI: 10.1016/j.isci.2023.106964.

Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair.

Gupta N, Matsumoto T, Hiratsuka K, Saiz E, Galichon P, Miyoshi T Sci Transl Med. 2022; 14(634):eabj4772.

PMID: 35235339 PMC: 9161367. DOI: 10.1126/scitranslmed.abj4772.

Disruption of RING and PHD Domains of TRIM28 Evokes Differentiation in Human iPSCs.

Mazurek S, Oleksiewicz U, Czerwinska P, Wroblewska J, Klimczak M, Wiznerowicz M Cells. 2021; 10(8).

PMID: 34440702 PMC: 8394524. DOI: 10.3390/cells10081933.

The Significance of NOTCH Pathway in the Development of Fibrosis in Systemic Sclerosis.

Zmorzynski S, Styk W, Filip A, Krasowska D Ann Dermatol. 2021; 31(4):365-371.

PMID: 33911613 PMC: 7992759. DOI: 10.5021/ad.2019.31.4.365.

TGF-β1 Signaling and Tissue Fibrosis.

Kim K, Sheppard D, Chapman H Cold Spring Harb Perspect Biol. 2017; 10(4).

PMID: 28432134 PMC: 5880172. DOI: 10.1101/cshperspect.a022293.

References
1.
Strutz F, Okada H, Lo C, Danoff T, Carone R, Tomaszewski J . Identification and characterization of a fibroblast marker: FSP1. J Cell Biol. 1995; 130(2):393-405. PMC: 2199940. DOI: 10.1083/jcb.130.2.393. View
2.
Mikheev A, Mikheev S, Zhang Y, Aebersold R, Zarbl H . CArG binding factor A (CBF-A) is involved in transcriptional regulation of the rat Ha-ras promoter. Nucleic Acids Res. 2000; 28(19):3762-70. PMC: 110773. DOI: 10.1093/nar/28.19.3762. View
3.
Schultz D, Friedman J, Rauscher 3rd F . Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Genes Dev. 2001; 15(4):428-43. PMC: 312636. DOI: 10.1101/gad.869501. View
4.
Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F . BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med. 2003; 9(7):964-8. DOI: 10.1038/nm888. View
5.
Kalluri R, Neilson E . Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 2003; 112(12):1776-84. PMC: 297008. DOI: 10.1172/JCI20530. View