Fast 3D Spatial EPR Imaging Using Spiral Magnetic Field Gradient

Overview

Journal J Magn Reson

Publisher Elsevier

Date 2007 Feb 3

PMID 17267252

Citations 13

Authors

Yuanmu Deng

Sergy Petryakov

Guanglong He

Eric Kesselring

Periannan Kuppusamy

Jay L Zweier

Affiliations

Soon will be listed here.

Abstract

Electron paramagnetic resonance imaging (EPRI) provides direct detection and mapping of free radicals. The continuous wave (CW) EPRI technique, in particular, has been widely used in a variety of applications in the fields of biology and medicine due to its high sensitivity and applicability to a wide range of free radicals and paramagnetic species. However, the technique requires long image acquisition periods, and this limits its use for many in vivo applications where relatively rapid changes occur in the magnitude and distribution of spins. Therefore, there has been a great need to develop fast EPRI techniques. We report the development of a fast 3D CW EPRI technique using spiral magnetic field gradient. By spiraling the magnetic field gradient and stepping the main magnetic field, this approach acquires a 3D image in one sweep of the main magnetic field, enabling significant reduction of the imaging time. A direct one-stage 3D image reconstruction algorithm, modified for reconstruction of the EPR images from the projections acquired with the spiral magnetic field gradient, was used. We demonstrated using a home-built L-band EPR system that the spiral magnetic field gradient technique enabled a 4-7-fold accelerated acquisition of projections. This technique has great potential for in vivo studies of free radicals and their metabolism.

Citing Articles

Development of a fast-scan EPR imaging system for highly accelerated free radical imaging.

Samouilov A, Ahmad R, Boslett J, Liu X, Petryakov S, Zweier J Magn Reson Med. 2019; 82(2):842-853.

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Electron paramagnetic resonance microscopy using spins in diamond under ambient conditions.

Simpson D, Ryan R, Hall L, Panchenko E, Drew S, Petrou S Nat Commun. 2017; 8(1):458.

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Uniform spinning sampling gradient electron paramagnetic resonance imaging.

Johnson D, Ahmad R, Liu Y, Chen Z, Samouilov A, Zweier J Magn Reson Med. 2013; 71(2):893-900.

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Fast gated EPR imaging of the beating heart: spatiotemporally resolved 3D imaging of free-radical distribution during the cardiac cycle.

Chen Z, Reyes L, Johnson D, Velayutham M, Yang C, Samouilov A Magn Reson Med. 2012; 69(2):594-601.

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ESR Microscopy for Biological and Biomedical Applications.

Shin C, Dunnam C, Borbat P, Dzikovski B, Barth E, Halpern H Nanosci Nanotechnol Lett. 2011; 3(4):561-567.

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