Uncrossed Actions of Feline Corticospinal Tract Neurones on Lumbar Interneurones Evoked Via Ipsilaterally Descending Pathways

Overview

Journal J Physiol

Specialty Physiology

Date 2007 Jan 27

PMID 17255170

Citations 13

Authors

E Jankowska

K Stecina

Affiliations

Soon will be listed here.

Abstract

Effects of stimulation of ipsilateral pyramidal tract (PT) fibres were analysed in interneurones in midlumbar segments of the cat spinal cord in search of interneurones mediating disynaptic actions of uncrossed PT fibres on hindlimb motoneurones. The sample included 44 intermediate zone and ventral horn interneurones, most with monosynaptic input from group I and/or group II muscle afferents and likely to be premotor interneurones. Monosynaptic EPSPs evoked by stimulation of the ipsilateral PT were found in 12 of the 44 (27%) interneurones, while disynaptic or trisynaptic EPSPs were evoked in more than 75%. Both appeared at latencies that were either longer or within the same range as those of disynaptic EPSPs and IPSPs evoked by PT stimuli in motoneurones, making it unlikely that premotor interneurones in pathways from group I and/or II afferents relay the earliest actions of uncrossed PT fibres on motoneurones. These interneurones might nevertheless contribute to PT actions at longer latencies. Uncrossed PT actions on interneurones were to a great extent relayed via reticulospinal neurones with axons in the ipsilateral medial longitudinal fascicle (MLF), as indicated by occlusion and mutual facilitation of actions evoked by PT and MLF stimulation. However, PT actions were also relayed by other supraspinal or spinal neurones, as some remained after MLF lesions. Mutual facilitation and occlusion of actions evoked from the ipsilateral and contralateral PTs lead to the conclusion that the same midlumbar interneurones in pathways from group I or II muscle afferents may relay uncrossed and crossed PT actions.

Citing Articles

Cortical Effects on Ipsilateral Hindlimb Muscles Revealed with Stimulus-Triggered Averaging of EMG Activity.

Messamore W, Van Acker 3rd G, Hudson H, Zhang H, Kovac A, Nazzaro J Cereb Cortex. 2015; 26(7):3036-51.

PMID: 26088970 PMC: 4898664. DOI: 10.1093/cercor/bhv122.

Facilitation of ipsilateral actions of corticospinal tract neurons on feline motoneurons by transcranial direct current stimulation.

Baczyk M, Pettersson L, Jankowska E Eur J Neurosci. 2014; 40(4):2628-40.

PMID: 24835584 PMC: 4142254. DOI: 10.1111/ejn.12623.

Recruitment of ipsilateral and contralateral upper limb muscles following stimulation of the cortical motor areas in the monkey.

Montgomery L, Herbert W, Buford J Exp Brain Res. 2013; 230(2):153-64.

PMID: 23852324 PMC: 3778999. DOI: 10.1007/s00221-013-3639-5.

Evidence for long-lasting subcortical facilitation by transcranial direct current stimulation in the cat.

Bolzoni F, Pettersson L, Jankowska E J Physiol. 2013; 591(13):3381-99.

PMID: 23507876 PMC: 3717234. DOI: 10.1113/jphysiol.2012.244764.

Cortical stimulation causes long-term changes in H-reflexes and spinal motoneuron GABA receptors.

Wang Y, Chen Y, Chen L, Wolpaw J, Chen X J Neurophysiol. 2012; 108(10):2668-78.

PMID: 22933718 PMC: 3545115. DOI: 10.1152/jn.00516.2012.

References

REXED B . A cytoarchitectonic atlas of the spinal cord in the cat. J Comp Neurol. 1954; 100(2):297-379. DOI: 10.1002/cne.901000205. View

Dum R, Strick P . Spinal cord terminations of the medial wall motor areas in macaque monkeys. J Neurosci. 1996; 16(20):6513-25. PMC: 6578918. View

Illert M, Lundberg A, PADEL Y, Tanaka R . Integration in descending motor pathways controlling the forelimb in the cat. 5. Properties of and monosynaptic excitatory convergence on C3--C4 propriospinal neurones. Exp Brain Res. 1978; 33(1):101-30. DOI: 10.1007/BF00238798. View

Hongo T, Kitazawa S, Ohki Y, Sasaki M, Xi M . A physiological and morphological study of premotor interneurones in the cutaneous reflex pathways in cats. Brain Res. 1989; 505(1):163-6. DOI: 10.1016/0006-8993(89)90131-5. View

WOOLSEY C, Chang H . Cortical origin of the pyramidal tract as defined by antidromic volleys from the medullary pyramid. Fed Proc. 2010; 6(1 Pt 2):230. View

Lundberg A, Norrsell U, VOORHOEVE P . Pyramidal effects on lumbo-sacral interneurones activated by somatic afferents. Acta Physiol Scand. 1962; 56:220-9. DOI: 10.1111/j.1748-1716.1962.tb02497.x. View

Hultborn H . Plateau potentials and their role in regulating motoneuronal firing. Prog Brain Res. 2000; 123:39-48. DOI: 10.1016/s0079-6123(08)62842-3. View

Hultborn H, Jankowska E, Lindstrom S . Recurrent inhibition of interneurones monosynaptically activated from group Ia afferents. J Physiol. 1971; 215(3):613-36. PMC: 1331904. DOI: 10.1113/jphysiol.1971.sp009488. View

Floeter M, Sholomenko G, Gossard J, Burke R . Disynaptic excitation from the medial longitudinal fasciculus to lumbosacral motoneurons: modulation by repetitive activation, descending pathways, and locomotion. Exp Brain Res. 1993; 92(3):407-19. DOI: 10.1007/BF00229029. View

10.

Jankowska E, Krutki P, Matsuyama K . Relative contribution of Ia inhibitory interneurones to inhibition of feline contralateral motoneurones evoked via commissural interneurones. J Physiol. 2005; 568(Pt 2):617-28. PMC: 1474749. DOI: 10.1113/jphysiol.2005.088351. View

11.

Cabaj A, Stecina K, Jankowska E . Same spinal interneurons mediate reflex actions of group Ib and group II afferents and crossed reticulospinal actions. J Neurophysiol. 2006; 95(6):3911-22. PMC: 1890023. DOI: 10.1152/jn.01262.2005. View

12.

Stecina K, Jankowska E . Uncrossed actions of feline corticospinal tract neurones on hindlimb motoneurones evoked via ipsilaterally descending pathways. J Physiol. 2007; 580(Pt 1):119-32. PMC: 2075439. DOI: 10.1113/jphysiol.2006.122721. View

13.

Jankowska E, Roberts W . Synaptic actions of single interneurones mediating reciprocal Ia inhibition of motoneurones. J Physiol. 1972; 222(3):623-42. PMC: 1331404. DOI: 10.1113/jphysiol.1972.sp009818. View

14.

Matsuyama K, Drew T . Organization of the projections from the pericruciate cortex to the pontomedullary brainstem of the cat: a study using the anterograde tracer Phaseolus vulgaris-leucoagglutinin. J Comp Neurol. 1998; 389(4):617-41. DOI: 10.1002/(sici)1096-9861(19971229)389:4<617::aid-cne6>3.0.co;2-3. View

15.

Davies H, Edgley S . Inputs to group II-activated midlumbar interneurones from descending motor pathways in the cat. J Physiol. 1994; 479 ( Pt 3):463-73. PMC: 1155764. DOI: 10.1113/jphysiol.1994.sp020310. View

16.

Jankowska E, Stecina K, Cabaj A, Pettersson L, Edgley S . Neuronal relays in double crossed pathways between feline motor cortex and ipsilateral hindlimb motoneurones. J Physiol. 2006; 575(Pt 2):527-41. PMC: 1819437. DOI: 10.1113/jphysiol.2006.112425. View

17.

Edgley S, Jankowska E . An interneuronal relay for group I and II muscle afferents in the midlumbar segments of the cat spinal cord. J Physiol. 1987; 389:647-74. PMC: 1192100. DOI: 10.1113/jphysiol.1987.sp016676. View

18.

Hongo T, Kitazawa S, Ohki Y, Xi M . Functional identification of last-order interneurones of skin reflex pathways in the cat forelimb segments. Brain Res. 1989; 505(1):167-70. DOI: 10.1016/0006-8993(89)90132-7. View

19.

Fetz E, Perlmutter S, Prut Y . Functions of mammalian spinal interneurons during movement. Curr Opin Neurobiol. 2001; 10(6):699-707. DOI: 10.1016/s0959-4388(00)00160-4. View

20.

Hounsgaard J, Hultborn H, Jespersen B, Kiehn O . Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J Physiol. 1988; 405:345-67. PMC: 1190979. DOI: 10.1113/jphysiol.1988.sp017336. View