Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice

Overview

Journal J Neurosci

Specialty Neurology

Date 2007 Jan 12

PMID 17215390

Citations 72

Authors

Yaoming Wang

Xiao Ou Mao

Lin Xie

Surita Banwait

Hugo H Marti

David A Greenberg

Kunlin Jin

Affiliations

Soon will be listed here.

Abstract

We sought genetic evidence for the involvement of neuronal vascular endothelial growth factor (VEGF) in amyotrophic lateral sclerosis (ALS). Mice expressing human ALS mutant superoxide dismutase-1 (SOD1) were crossed with mice that overexpress VEGF in neurons (VEGF+/+). We report that SOD1(G93A)/VEGF+/+ double-transgenic mice show delayed motor neuron loss, delayed motor impairment, and prolonged survival compared with SOD1(G93A) single transgenics. These findings indicate that neuronal VEGF protects against motor neuron degeneration, and may have therapeutic implications for ALS.

Citing Articles

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Role of vascular endothelial growth factor as a critical neurotrophic factor for the survival and physiology of motoneurons.

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VEGF is an essential retrograde trophic factor for motoneurons.

Calvo P, Hernandez R, de la Cruz R, Pastor A Proc Natl Acad Sci U S A. 2022; 119(26):e2202912119.

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