Maspin Nuclear Localization is Related to Reduced Density of Tumour-associated Micro-vessels in Laryngeal Carcinoma

Overview

Journal Anticancer Res

Specialty Oncology

Date 2007 Jan 12

PMID 17214364

Citations 11

Authors

Gino Marioni

Emiliano DAlessandro

Luciano Giacomelli

Cosimo de Filippis

Nicola Calgaro

Marianna Sari

Alberto Staffieri

Stella Blandamura

Affiliations

Soon will be listed here.

Abstract

Background: MASPIN, a tumour suppressing serpin, is a potent inhibitor of angiogenesis. CD105 is a proliferation-associated protein acting in endothelial cells of angiogenic tissues. For the first time the relation between nuclear MASPIN expression and CD105-assessed micro-vessel density (MVD) in laryngeal carcinoma was investigated.

Patients And Methods: The sub-cellular distribution of MASPIN and nuclear MASPIN expression were immunohistochemically determined in 35 cases of laryngeal carcinoma. The percentage of the fields occupied by CDl05-assessed micro-vessels was also calculated.

Results: MVD was significantly lower in laryngeal carcinomas with MASPIN nuclear staining than in carcinomas with cytoplasmic staining (p=0.02). The mean nuclear MASPIN expression was higher in patients without carcinoma recurrence than in those with recurrence (p=0.06). The mean MVD was significantly higher in patients with recurrence of carcinoma (p=0.024).

Conclusion: The crucial role of MASPIN nuclear localization in reducing the MVD has been demonstrated. Nuclear MASPIN re-expression should be investigated as a potential therapeutic option in the treatment of laryngeal carcinoma.

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