Temporal Bone Squamous Cell Carcinoma: Molecular Markers Involved in Carcinogenesis, Behavior, and Prognosis: A Systematic Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 May 14

PMID 35562926

Authors

Lara Alessandrini

Laura Astolfi

Leonardo Franz

Erica Gentilin

Antonio Mazzoni

Elisabetta Zanoletti

Gino Marioni

Affiliations

Soon will be listed here.

Abstract

Temporal bone squamous cell carcinoma (TBSCC) is an uncommon malignancy with a poor prognosis in advanced cases. The dismal outcome of advanced TBSSC cases is largely due to the cancer's local aggressiveness and the complex anatomy of this region, as well as to persistent pitfalls in diagnosis and treatment. Molecular changes occur in malignancies before any morphological changes become visible, and are responsible for the disease's clinical behavior. The main purpose of this critical systematic review is to assess the level of knowledge on the molecular markers involved in the biology, behavior, and prognosis of TBSCC. A search (updated to March 2022) was run in PubMed, Scopus, and Web of Science electronic databases without publication date limits for studies investigating molecular markers in cohorts of patients with primary TBSCC. The search terms used were: "temporal bone" OR "external auditory canal" OR "ear", AND "cancer" OR "carcinoma" OR "malignancy". We preliminarily decided not to consider series with less than five cases. Twenty-four case series of TBSCC were found in which different analytical techniques had been used to study the role of several biomarkers. In conclusion, only very limited information on the prognostic role of molecular markers in TBSCC are currently available; prospective, multi-institutional, international prognostic studies should be planned to identify the molecular markers involved in the clinical behavior and prognosis of TBSCC. A further, more ambitious goal would be to find targets for therapeutic agents able to improve disease-specific survival in patients with advanced TBSCC.

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References

Yasumatsu R, Wakasaki T, Hashimoto K, Nakashima K, Manako T, Taura M . Monitoring the neutrophil-to-lymphocyte ratio may be useful for predicting the anticancer effect of nivolumab in recurrent or metastatic head and neck cancer. Head Neck. 2019; 41(8):2610-2618. DOI: 10.1002/hed.25737. View

Dzikiewicz-Krawczyk A, Kok K, Slezak-Prochazka I, Robertus J, Bruining J, Tayari M . ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma. Leukemia. 2017; 31(6):1470-1473. DOI: 10.1038/leu.2017.94. View

Yu H, Lee H, Herrmann A, Buettner R, Jove R . Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer. 2014; 14(11):736-46. DOI: 10.1038/nrc3818. View

Lovato A, Franz L, Carraro V, Bandolin L, Contro G, Ottaviano G . Maspin expression and anti-apoptotic pathway regulation by bcl2 in laryngeal cancer. Ann Diagn Pathol. 2020; 45:151471. DOI: 10.1016/j.anndiagpath.2020.151471. View

Liu X, Wang W, Chen J, Chen C, Zhou J, Cao L . Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec. 2011; 74(1):16-21. DOI: 10.1159/000334243. View

Ferlin A, Pepe A, Facciolli A, Gianesello L, Foresta C . Relaxin stimulates osteoclast differentiation and activation. Bone. 2009; 46(2):504-13. DOI: 10.1016/j.bone.2009.10.007. View

Ramos-Garcia P, Gonzalez-Moles M . Prognostic and Clinicopathological Significance of the Aberrant Expression of β-Catenin in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Cancers (Basel). 2022; 14(3). PMC: 8833491. DOI: 10.3390/cancers14030479. View

Fanali G, Di Masi A, Trezza V, Marino M, Fasano M, Ascenzi P . Human serum albumin: from bench to bedside. Mol Aspects Med. 2012; 33(3):209-90. DOI: 10.1016/j.mam.2011.12.002. View

Zanoletti E, Franz L, Cazzador D, Franchella S, Calvanese L, Nicolai P . Temporal bone carcinoma: Novel prognostic score based on clinical and histological features. Head Neck. 2020; 42(12):3693-3701. DOI: 10.1002/hed.26435. View

10.

Hanna G, Lizotte P, Cavanaugh M, Kuo F, Shivdasani P, Frieden A . Frameshift events predict anti-PD-1/L1 response in head and neck cancer. JCI Insight. 2018; 3(4). PMC: 5916245. DOI: 10.1172/jci.insight.98811. View

11.

Basura G, Smith J, Ellsperman S, Bhangale A, Brenner J . Targeted molecular characterization of external auditory canal squamous cell carcinomas. Laryngoscope Investig Otolaryngol. 2021; 6(5):1151-1157. PMC: 8513438. DOI: 10.1002/lio2.654. View

12.

Liu H, Dai C, Wu Q, Liu H, Li F . Expression profiling of long noncoding RNA identifies lnc-MMP3-1 as a prognostic biomarker in external auditory canal squamous cell carcinoma. Cancer Med. 2017; 6(11):2541-2551. PMC: 5673923. DOI: 10.1002/cam4.1213. View

13.

Okado Y, Aoki M, Hamasaki M, Koga K, Sueta T, Shiratsuchi H . Tumor budding and laminin5-γ2 in squamous cell carcinoma of the external auditory canal are associated with shorter survival. Springerplus. 2016; 4:814. PMC: 4690822. DOI: 10.1186/s40064-015-1620-4. View

14.

Yue H, Cai Y, Song Y, Meng L, Chen X, Wang M . Elevated TARP promotes proliferation and metastasis of salivary adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017; 123(4):468-476. DOI: 10.1016/j.oooo.2016.11.023. View

15.

Xu T, Shen C, Wei Y, Hu C, Wang Y, Xiang J . Human papillomavirus (HPV) in Chinese oropharyngeal squamous cell carcinoma (OPSCC): A strong predilection for the tonsil. Cancer Med. 2020; 9(18):6556-6564. PMC: 7520352. DOI: 10.1002/cam4.3339. View

16.

Facciolli A, Ferlin A, Gianesello L, Pepe A, Foresta C . Role of relaxin in human osteoclastogenesis. Ann N Y Acad Sci. 2009; 1160:221-5. DOI: 10.1111/j.1749-6632.2008.03788.x. View

17.

Marioni G, Zanoletti E, Lovato A, Franchella S, Giacomelli L, Gianatti A . Relaxin-2 expression in temporal bone carcinoma. Eur Arch Otorhinolaryngol. 2014; 272(11):3225-32. DOI: 10.1007/s00405-014-3383-x. View

18.

Wendt M, Allington T, Schiemann W . Mechanisms of the epithelial-mesenchymal transition by TGF-beta. Future Oncol. 2009; 5(8):1145-68. PMC: 2858056. DOI: 10.2217/fon.09.90. View

19.

Sekino Y, Imaizumi A, Komune N, Ono M, Sato K, Masuda S . Establishment and characterization of a primary cell culture derived from external auditory canal squamous cell carcinoma. FEBS Open Bio. 2021; 11(8):2211-2224. PMC: 8329851. DOI: 10.1002/2211-5463.13225. View

20.

Grandis J, Drenning S, Zeng Q, Watkins S, Melhem M, Endo S . Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A. 2000; 97(8):4227-32. PMC: 18206. DOI: 10.1073/pnas.97.8.4227. View