The Association Between Hepatitis C Infection and Prevalent Cardiovascular Disease Among HIV-infected Individuals

Overview

Journal AIDS

Specialty Infectious Diseases

Date 2007 Jan 2

PMID 17197810

Citations 27

Authors

Matthew S Freiberg

Debbie M Cheng

Kevin L Kraemer

Richard Saitz

Lewis H Kuller

Jeffrey H Samet

Affiliations

Soon will be listed here.

Abstract

Objective: To examine the association between hepatitis C and prevalent cardiovascular disease (CVD) among HIV-infected individuals.

Design: A cross-sectional analysis of data from the HIV-Longitudinal Interrelationships of Viruses and Ethanol (HIV-LIVE) cohort, a prospective cohort of HIV-infected individuals with current or past alcohol problems.

Methods: We analysed health questionnaire and laboratory data from 395 HIV-infected individuals (50.1% co-infected with hepatitis C) using logistic regression to estimate the odds ratio (OR) for the prevalence of CVD among those co-infected with hepatitis C and HIV compared with those infected with HIV alone.

Results: The prevalence of CVD was higher among those co-infected with hepatitis C compared with those with HIV alone (11.1 versus 2.5%, respectively). After adjusting for age, the OR for the prevalence of CVD was significantly higher among those with hepatitis C co-infection (adjusted OR 4.65, 95% confidence interval 1.70-12.71). The relationship between hepatitis C and CVD persisted when adjusting for age and other sociodemographic characteristics, substance use, and cardiovascular risk factors in separate regression models.

Conclusion: Co-infection with hepatitis C among a cohort of HIV-infected individuals was associated with a higher age-adjusted odds for the prevalence of CVD. These data suggest that hepatitis C infection may be associated with an increased risk of CVD among those co-infected with HIV.

Citing Articles

Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease.

Obare L, Temu T, Mallal S, Wanjalla C Circ Res. 2024; 134(11):1515-1545.

PMID: 38781301 PMC: 11122788. DOI: 10.1161/CIRCRESAHA.124.323891.

Association between treatment of hepatitis C virus and risk of cardiovascular disease among insured patients with the virus in the United States.

Wang W, Chen C, Lo Re 3rd V, Chang S, Wilson D, Park H Pharmacoepidemiol Drug Saf. 2023; 32(10):1142-1151.

PMID: 37278688 PMC: 10655016. DOI: 10.1002/pds.5651.

CD4 T cells expressing CX3CR1, GPR56, with variable CD57 are associated with cardiometabolic diseases in persons with HIV.

Wanjalla C, Gabriel C, Fuseini H, Bailin S, Mashayekhi M, Simmons J Front Immunol. 2023; 14:1099356.

PMID: 36865544 PMC: 9971959. DOI: 10.3389/fimmu.2023.1099356.

Assessing the health status and mortality of older people over 65 with HIV.

Turrini G, Chan S, Klein P, Cohen S, Dempsey A, Hauck H PLoS One. 2020; 15(11):e0241833.

PMID: 33152053 PMC: 7644038. DOI: 10.1371/journal.pone.0241833.

Risk of Cardiovascular Disease Due to Chronic Hepatitis C Infection: A Review.

Babiker A, Jeudy J, Kligerman S, Khambaty M, Shah A, Bagchi S J Clin Transl Hepatol. 2017; 5(4):343-362.

PMID: 29226101 PMC: 5719192. DOI: 10.14218/JCTH.2017.00021.

References

Volzke H, Schwahn C, Wolff B, Mentel R, Robinson D, Kleine V . Hepatitis B and C virus infection and the risk of atherosclerosis in a general population. Atherosclerosis. 2004; 174(1):99-103. DOI: 10.1016/j.atherosclerosis.2004.01.010. View

Ishizaka N, Ishizaka Y, Takahashi E, Tooda E, Hashimoto H, Nagai R . Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening. Lancet. 2002; 359(9301):133-5. DOI: 10.1016/s0140-6736(02)07339-7. View

Buchsbaum D, Buchanan R, Centor R, Schnoll S, LAWTON M . Screening for alcohol abuse using CAGE scores and likelihood ratios. Ann Intern Med. 1991; 115(10):774-7. DOI: 10.7326/0003-4819-115-10-774. View

Chiu B, Viira E, Tucker W, Fong I . Chlamydia pneumoniae, cytomegalovirus, and herpes simplex virus in atherosclerosis of the carotid artery. Circulation. 1997; 96(7):2144-8. DOI: 10.1161/01.cir.96.7.2144. View

Anderson K, Guest J, Rimland D . Hepatitis C virus coinfection increases mortality in HIV-infected patients in the highly active antiretroviral therapy era: data from the HIV Atlanta VA Cohort Study. Clin Infect Dis. 2004; 39(10):1507-13. DOI: 10.1086/425360. View

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

Momiyama Y, Ohmori R, Kato R, Taniguchi H, Nakamura H, Ohsuzu F . Lack of any association between persistent hepatitis B or C virus infection and coronary artery disease. Atherosclerosis. 2005; 181(1):211-3. DOI: 10.1016/j.atherosclerosis.2005.02.027. View

Butt A, Evans R, Skanderson M, Shakil A . Comorbid medical and psychiatric conditions and substance abuse in HCV infected persons on dialysis. J Hepatol. 2006; 44(5):864-8. DOI: 10.1016/j.jhep.2006.01.024. View

Libman H, Saitz R, Nunes D, Cheng D, Richardson J, Vidaver J . Hepatitis C infection is associated with depressive symptoms in HIV-infected adults with alcohol problems. Am J Gastroenterol. 2006; 101(8):1804-10. PMC: 1592346. DOI: 10.1111/j.1572-0241.2006.00616.x. View

10.

Sherman K, Rouster S, Chung R, Rajicic N . Hepatitis C Virus prevalence among patients infected with Human Immunodeficiency Virus: a cross-sectional analysis of the US adult AIDS Clinical Trials Group. Clin Infect Dis. 2002; 34(6):831-7. DOI: 10.1086/339042. View

11.

Liang T, Rehermann B, Seeff L, Hoofnagle J . Pathogenesis, natural history, treatment, and prevention of hepatitis C. Ann Intern Med. 2000; 132(4):296-305. DOI: 10.7326/0003-4819-132-4-200002150-00008. View

12.

Mehta S, Brancati F, Sulkowski M, Strathdee S, Szklo M, Thomas D . Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States. Ann Intern Med. 2000; 133(8):592-9. DOI: 10.7326/0003-4819-133-8-200010170-00009. View

13.

Siscovick D, Schwartz S, Corey L, GRAYSTON J, Ashley R, Wang S . Chlamydia pneumoniae, herpes simplex virus type 1, and cytomegalovirus and incident myocardial infarction and coronary heart disease death in older adults : the Cardiovascular Health Study. Circulation. 2000; 102(19):2335-40. DOI: 10.1161/01.cir.102.19.2335. View

14.

Shah P . Link between infection and atherosclerosis: who are the culprits: viruses, bacteria, both, or neither?. Circulation. 2001; 103(1):5-6. DOI: 10.1161/01.cir.103.1.5. View

15.

Carr A, Emery S, Law M, Puls R, Lundgren J, Powderly W . An objective case definition of lipodystrophy in HIV-infected adults: a case-control study. Lancet. 2003; 361(9359):726-35. DOI: 10.1016/s0140-6736(03)12656-6. View

16.

Tedaldi E, Baker R, Moorman A, Alzola C, Furhrer J, McCabe R . Influence of coinfection with hepatitis C virus on morbidity and mortality due to human immunodeficiency virus infection in the era of highly active antiretroviral therapy. Clin Infect Dis. 2003; 36(3):363-7. DOI: 10.1086/345953. View

17.

Tomiyama H, Arai T, Hirose K, Hori S, Yamamoto Y, Yamashina A . Hepatitis C virus seropositivity, but not hepatitis B virus carrier or seropositivity, associated with increased pulse wave velocity. Atherosclerosis. 2003; 166(2):401-3. DOI: 10.1016/s0021-9150(02)00388-x. View

18.

Ishizaka Y, Ishizaka N, Takahashi E, Unuma T, Tooda E, Hashimoto H . Association between hepatitis C virus core protein and carotid atherosclerosis. Circ J. 2003; 67(1):26-30. DOI: 10.1253/circj.67.26. View

19.

Vassalle C, Masini S, Bianchi F, Zucchelli G . Evidence for association between hepatitis C virus seropositivity and coronary artery disease. Heart. 2004; 90(5):565-6. PMC: 1768206. DOI: 10.1136/hrt.2003.018937. View

20.

Friis-Moller N, Sabin C, Weber R, Monforte A, El-Sadr W, Reiss P . Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med. 2003; 349(21):1993-2003. DOI: 10.1056/NEJMoa030218. View