Polyreactive Myelin Oligodendrocyte Glycoprotein Antibodies: Implications for Systemic Autoimmunity in Progressive Experimental Autoimmune Encephalomyelitis

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 2007 Jan 2

PMID 17197039

Citations 7

Authors

Lisa K Peterson

Ikuo Tsunoda

Takahisa Masaki

Robert S Fujinami

Affiliations

Soon will be listed here.

Abstract

Two myelin oligodendrocyte glycoprotein (MOG92-106) monoclonal antibodies (mAbs) were produced from an A.SW mouse with progressive experimental autoimmune encephalomyelitis. Polyreactivity/specificity of the mAbs was demonstrated by ELISA. Functionality and a potential role in pathogenesis of systemic autoimmunity were demonstrated in vitro in a lymphocytotoxicity assay and in vivo upon injection into naïve mice. Injection of MOG mAb producing hybridomas into naïve mice resulted in immunoglobulin deposition in kidneys and liver. This model will be useful in determining whether transitional forms between CNS (organ)-specific and systemic autoimmune diseases exist, and whether progressive multiple sclerosis has features of a systemic autoimmune disease.

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