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In Vino Veritas: a Tale of Two Sirt1s?

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 2006 Dec 19
PMID 17174885
Citations 21
Authors
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Abstract

Resveratrol increases life span in lower organisms by activating the NAD(+)-dependent histone deacetylase Sirt1. Studies by and now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1alpha.

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