Rehabilitation and the Single Cell

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2006 Dec 19

PMID 17174083

Citations 34

Authors

William M Bement

Hoi-Ying E Yu

Brian M Burkel

Emily M Vaughan

Andrew G Clark

Affiliations

Soon will be listed here.

Abstract

Cellular damage triggers rapid resealing of the plasma membrane and repair of the cortical cytoskeleton. Plasma membrane resealing results from calcium-dependent fusion of membranous organelles and the plasma membrane at the site of the damage. Cortical cytoskeletal repair results from local assembly of actin filaments (F-actin), myosin-2 and microtubules into an array that closes around the original wound site. Control of the cytoskeletal response is exerted by local activation of the small GTPases, Rho and Cdc42. Recent work has given insight into both the membrane fusion and cytoskeletal responses to plasma membrane damage and we propose that Rho GTPase activation results at least in part from the events that drive membrane repair.

Citing Articles

Membrane Tension Regulation is Required for Wound Repair.

Raj N, Weiss M, Vos B, Weischer S, Brinkmann F, Betz T Adv Sci (Weinh). 2024; 11(48):e2402317.

PMID: 39360573 PMC: 11672324. DOI: 10.1002/advs.202402317.

Physical Forces in Regeneration of Cells and Tissues.

Tang S, Marshall W Cold Spring Harb Perspect Biol. 2024; .

PMID: 38806241 PMC: 11602525. DOI: 10.1101/cshperspect.a041527.

Two Septin complexes mediate actin dynamics during cell wound repair.

Stjepic V, Nakamura M, Hui J, Parkhurst S Cell Rep. 2024; 43(5):114215.

PMID: 38728140 PMC: 11203717. DOI: 10.1016/j.celrep.2024.114215.

Wound Repair of the Cell Membrane: Lessons from Cells.

Yumura S Cells. 2024; 13(4.

PMID: 38391954 PMC: 10886852. DOI: 10.3390/cells13040341.

Two Septin Complexes Mediate Actin Dynamics During Cell Wound Repair.

Stjepic V, Nakamura M, Hui J, Parkhurst S bioRxiv. 2023; .

PMID: 38014090 PMC: 10680708. DOI: 10.1101/2023.11.14.567084.

References

Yasuda S, Townsend D, Michele D, Favre E, Day S, Metzger J . Dystrophic heart failure blocked by membrane sealant poloxamer. Nature. 2005; 436(7053):1025-9. DOI: 10.1038/nature03844. View

Sokac A, Co C, Taunton J, Bement W . Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs. Nat Cell Biol. 2003; 5(8):727-32. DOI: 10.1038/ncb1025. View

Lennon N, Kho A, Bacskai B, Perlmutter S, Hyman B, Brown Jr R . Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem. 2003; 278(50):50466-73. DOI: 10.1074/jbc.M307247200. View

Mehendale H, Limaye P . Calpain: a death protein that mediates progression of liver injury. Trends Pharmacol Sci. 2005; 26(5):232-6. DOI: 10.1016/j.tips.2005.03.008. View

Shen S, Steinhardt R . The mechanisms of cell membrane resealing in rabbit corneal epithelial cells. Curr Eye Res. 2005; 30(7):543-54. DOI: 10.1080/02713680590968574. View

Andrews N . Lysosomes and the plasma membrane: trypanosomes reveal a secret relationship. J Cell Biol. 2002; 158(3):389-94. PMC: 2173812. DOI: 10.1083/jcb.200205110. View

Krause T, Fishman H, Ballinger M, Bittner G . Extent and mechanism of sealing in transected giant axons of squid and earthworms. J Neurosci. 1994; 14(11 Pt 1):6638-51. PMC: 6577266. View

Huynh C, Andrews N . The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis. EMBO Rep. 2005; 6(9):843-7. PMC: 1369166. DOI: 10.1038/sj.embor.7400495. View

Doherty K, Cave A, Davis D, Delmonte A, Posey A, Earley J . Normal myoblast fusion requires myoferlin. Development. 2005; 132(24):5565-75. PMC: 4066872. DOI: 10.1242/dev.02155. View

10.

Bement W, Capco D . Analysis of inducible contractile rings suggests a role for protein kinase C in embryonic cytokinesis and wound healing. Cell Motil Cytoskeleton. 1991; 20(2):145-57. DOI: 10.1002/cm.970200207. View

11.

Jaiswal J, Andrews N, Simon S . Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells. J Cell Biol. 2002; 159(4):625-35. PMC: 2173094. DOI: 10.1083/jcb.200208154. View

12.

Darenfed H, Mandato C . Wound-induced contractile ring: a model for cytokinesis. Biochem Cell Biol. 2005; 83(6):711-20. DOI: 10.1139/o05-164. View

13.

Borgonovo B, Cocucci E, Racchetti G, Podini P, Bachi A, Meldolesi J . Regulated exocytosis: a novel, widely expressed system. Nat Cell Biol. 2002; 4(12):955-62. DOI: 10.1038/ncb888. View

14.

Fein A, Terasaki M . Rapid increase in plasma membrane chloride permeability during wound resealing in starfish oocytes. J Gen Physiol. 2005; 126(2):151-9. PMC: 2266568. DOI: 10.1085/jgp.200509294. View

15.

Cocucci E, Racchetti G, Podini P, Rupnik M, Meldolesi J . Enlargeosome, an exocytic vesicle resistant to nonionic detergents, undergoes endocytosis via a nonacidic route. Mol Biol Cell. 2004; 15(12):5356-68. PMC: 532016. DOI: 10.1091/mbc.e04-07-0577. View

16.

Chakrabarti S, Kobayashi K, Flavell R, Marks C, Miyake K, Liston D . Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J Cell Biol. 2003; 162(4):543-9. PMC: 2173791. DOI: 10.1083/jcb.200305131. View

17.

cerny J, Feng Y, Yu A, Miyake K, Borgonovo B, Klumperman J . The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep. 2004; 5(9):883-8. PMC: 1299144. DOI: 10.1038/sj.embor.7400243. View

18.

Benink H, Bement W . Concentric zones of active RhoA and Cdc42 around single cell wounds. J Cell Biol. 2005; 168(3):429-39. PMC: 2171735. DOI: 10.1083/jcb.200411109. View

19.

Rodriguez A, Webster P, Ortego J, Andrews N . Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells. J Cell Biol. 1997; 137(1):93-104. PMC: 2139854. DOI: 10.1083/jcb.137.1.93. View

20.

McNeil P, Vogel S, Miyake K, Terasaki M . Patching plasma membrane disruptions with cytoplasmic membrane. J Cell Sci. 2000; 113 ( Pt 11):1891-902. DOI: 10.1242/jcs.113.11.1891. View