HMG Chromosomal Proteins in Development and Disease

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2006 Dec 16

PMID 17169561

Citations 181

Authors

Robert Hock

Takashi Furusawa

Tetsuya Ueda

Michael Bustin

Affiliations

Soon will be listed here.

Abstract

The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the chromatin fiber. They are important in chromatin dynamics and influence DNA processing in the context of chromatin. Results emerging from studies of human disease, genetically modified mice and cells with altered HMG expression indicate that the expression of the HMG proteins is developmentally regulated and that changes in HMG protein levels alter the cellular phenotype and can lead to developmental abnormalities and disease. Here, we focus on the biological function of HMG proteins and highlight their possible roles in cellular differentiation and in the etiology of various diseases.

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