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Frequent Hypermethylation of the DNA Repair Gene MGMT in Long-term Survivors of Glioblastoma Multiforme

Overview
Journal J Neurooncol
Publisher Springer
Date 2006 Dec 14
PMID 17164975
Citations 46
Authors
Ramon Martinez
Gabriele Schackert
Ricard Yaya-Tur
Inigo Rojas-Marcos
James G Herman
Manel Esteller
Affiliations
Soon will be listed here.
Abstract

We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, P = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype.

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