Antigen-specific T-lymphocyte Function After Cord Blood Transplantation

Overview

Journal Biol Blood Marrow Transplant

Date 2006 Dec 13

PMID 17162216

Citations 22

Authors

Geoff Cohen

Shelly L Carter

Kenneth I Weinberg

Bernadette Masinsin

Eva Guinan

Joanne Kurtzberg

John E Wagner

Nancy A Kernan

Robertson Parkman

Affiliations

Soon will be listed here.

Abstract

It has not been possible to determine the singular contribution of naive T lymphocytes to antigen-specific immunity after hematopoietic stem cell transplantation (HSCT), because of the confounding effects of donor-derived antigen-specific T lymphocytes present in most hematopoietic stem cell (HSC) products. Because umbilical cord blood contains only naive T lymphocytes, we longitudinally evaluated the recipients of unrelated cord blood transplantation (UCBT) for the presence of T lymphocytes with specificity for herpesviruses, to determine the contribution of the naive T lymphocytes to antigen-specific immune reconstitution after HSCT. Antigen-specific T lymphocytes were detected early after UCBT (herpes simplex virus on day 29; cytomegalovirus on day 44; varicella zoster virus on day 94). Overall, 66 of 153 UCBT recipients developed antigen-specific T lymphocytes to 1 or more herpesviruses during the evaluation period. The likelihood of developing antigen-specific T lymphocyte function was not associated with immunophenotypic T lymphocyte reconstitution, transplant cell dose, primary disease, or acute and chronic graft-versus-host disease. These results indicate that naive T lymphocytes present in the HSC inoculum can contribute to the generation of antigen-specific T-lymphocyte immunity early after transplantation.

Citing Articles

Impact of HLA class I allele-level mismatch on viral infection within 100 days after cord blood transplantation.

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Clinical Grade Production of Wilms' Tumor-1 Loaded Cord Blood-Derived Dendritic Cells to Prevent Relapse in Pediatric AML After Cord Blood Transplantation.

Plantinga M, Lo Presti V, de Haar C, Dunnebach E, Madrigal A, Lindemans C Front Immunol. 2020; 11:559152.

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Robust CD4+ T-cell recovery in adults transplanted with cord blood and no antithymocyte globulin.

Politikos I, Lavery J, Hilden P, Cho C, Borrill T, Maloy M Blood Adv. 2020; 4(1):191-202.

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Myeloablative conditioning regimens with combined of haploidentical and cord blood transplantation for myelodysplastic syndrome patients.

Ke P, Bao X, Hu X, Zhuang J, Wu X, Liu Y Bone Marrow Transplant. 2017; 53(2):162-168.

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Immune reconstitution and outcomes after conditioning with anti-thymocyte-globulin in unrelated cord blood transplantation; the good, the bad, and the ugly.

de Koning C, Admiraal R, Nierkens S, Boelens J Stem Cell Investig. 2017; 4:38.

PMID: 28607912 PMC: 5460145. DOI: 10.21037/sci.2017.05.02.

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