Cell Cycle Control of Embryonic Stem Cells

Overview

Journal Stem Cell Rev

Specialty Cell Biology

Date 2006 Dec 5

PMID 17142847

Citations 168

Authors

Josephine White

Stephen Dalton

Affiliations

Soon will be listed here.

Abstract

Embryonic stem cells have the capacity for unlimited proliferation while retaining their potential to differentiate into a wide variety of cell types. Murine, primate and human embryonic stem cells (ESCs) exhibit a very unusual cell cycle structure, characterized by a short G1 phase and a high proportion of cells in S-phase. In the case of mESCs, this is associated with a unique mechanism of cell cycle regulation, underpinned by the precocious activity of cyclin dependent protein kinase (Cdk) activities. As ES cells differentiate, their cell cycle structure changes dramatically so as to incorporate a significantly longer G1 phase and their mechanism of cell cycle regulation changes to that typically seen in other mammalian cells. The unique cell cycle structure and mechanism of cell cycle control indicates that the cell cycle machinery plays a role in establishment or maintenance of the stem cell state. This idea is supported by the frequent involvement of cell cycle regulatory molecules in cell immortalization.

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References

Vidal A, Koff A . Cell-cycle inhibitors: three families united by a common cause. Gene. 2000; 247(1-2):1-15. DOI: 10.1016/s0378-1119(00)00092-5. View

Ciemerych M, Kenney A, Sicinska E, Kalaszczynska I, Bronson R, Rowitch D . Development of mice expressing a single D-type cyclin. Genes Dev. 2002; 16(24):3277-89. PMC: 187507. DOI: 10.1101/gad.1023602. View

Wianny F, Real F, Mummery C, van Rooijen M, Lahti J, Samarut J . G1-phase regulators, cyclin D1, cyclin D2, and cyclin D3: up-regulation at gastrulation and dynamic expression during neurulation. Dev Dyn. 1998; 212(1):49-62. DOI: 10.1002/(SICI)1097-0177(199805)212:1<49::AID-AJA5>3.0.CO;2-2. View

Quelle D, Ashmun R, Shurtleff S, Kato J, Bar-Sagi D, Roussel M . Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev. 1993; 7(8):1559-71. DOI: 10.1101/gad.7.8.1559. View

Hinds P, Mittnacht S, Dulic V, Arnold A, Reed S, Weinberg R . Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell. 1992; 70(6):993-1006. DOI: 10.1016/0092-8674(92)90249-c. View

Newport J, Kirschner M . A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. Cell. 1982; 30(3):675-86. DOI: 10.1016/0092-8674(82)90272-0. View

Cobrinik D, Lee M, Hannon G, Mulligan G, Bronson R, Dyson N . Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 1996; 10(13):1633-44. DOI: 10.1101/gad.10.13.1633. View

Polyak K, Kato J, Solomon M, Sherr C, Massague J, Roberts J . p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 1994; 8(1):9-22. DOI: 10.1101/gad.8.1.9. View

He T, Sparks A, Rago C, Hermeking H, Zawel L, DA COSTA L . Identification of c-MYC as a target of the APC pathway. Science. 1998; 281(5382):1509-12. DOI: 10.1126/science.281.5382.1509. View

10.

Field S, Tsai F, Kuo F, Zubiaga A, Kaelin Jr W, Livingston D . E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 1996; 85(4):549-61. DOI: 10.1016/s0092-8674(00)81255-6. View

11.

Dulic V, Kaufmann W, Wilson S, Tlsty T, Lees E, Harper J . p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell. 1994; 76(6):1013-23. DOI: 10.1016/0092-8674(94)90379-4. View

12.

Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson N . Tumor induction and tissue atrophy in mice lacking E2F-1. Cell. 1996; 85(4):537-48. DOI: 10.1016/s0092-8674(00)81254-4. View

13.

Stiffler L, Ji J, Trautmann S, Trusty C, Schubiger G . Cyclin A and B functions in the early Drosophila embryo. Development. 1999; 126(23):5505-13. DOI: 10.1242/dev.126.23.5505. View

14.

Lee M, Williams B, Mulligan G, Mukai S, Bronson R, Dyson N . Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 1996; 10(13):1621-32. DOI: 10.1101/gad.10.13.1621. View

15.

El-Deiry W, Harper J, OConnor P, Velculescu V, Canman C, Jackman J . WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 1994; 54(5):1169-74. View

16.

Liang J, Slingerland J . Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle. 2003; 2(4):339-45. View

17.

Stead E, White J, Faast R, Conn S, Goldstone S, Rathjen J . Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene. 2002; 21(54):8320-33. DOI: 10.1038/sj.onc.1206015. View

18.

Kane D, Warga R, Kimmel C . Mitotic domains in the early embryo of the zebrafish. Nature. 1992; 360(6406):735-7. DOI: 10.1038/360735a0. View

19.

Keyomarsi K, Conte Jr D, Toyofuku W, Fox M . Deregulation of cyclin E in breast cancer. Oncogene. 1995; 11(5):941-50. View

20.

Mummery C, van Rooijen M, van den Brink S, de Laat S . Cell cycle analysis during retinoic acid induced differentiation of a human embryonal carcinoma-derived cell line. Cell Differ. 1987; 20(2-3):153-60. DOI: 10.1016/0045-6039(87)90429-5. View