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International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor Alpha, Farnesoid X Receptor Beta, Liver X Receptor Alpha, Liver X Receptor Beta, and Vitamin D...

Overview
Journal Pharmacol Rev
Specialty Pharmacology
Date 2006 Nov 30
PMID 17132852
Citations 70
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Abstract

The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.

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