Downward Regulation of Neutrophil Infiltration by Endogenous Histamine Without Affecting Vascular Permeability Responses in Air-pouch-type Carrageenin Inflammation in Rats

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 1991 Apr 1

PMID 1712757

Citations 10

Authors

N Hirasawa

M Watanabe

S MUE

S Tsurufuji

K Ohuchi

Affiliations

Soon will be listed here.

Abstract

The role of histamine in neutrophil infiltration and vascular permeability response in carrageenin air pouch inflammation in rats was examined. Injection of carrageenin solution into an air pouch induced a gradual increase in histamine content in the pouch fluid and histidine decarboxylase activity of pouch wall tissues, with a maximum attained at 24 h. Local administration of the H2 antagonists cimetidine and famotidine, but not the H1 antagonist pyrilamine, induced an increase in neutrophil infiltration at 24 h. Both types of histamine antagonists failed to suppress the vascular permeability response. In addition, H2 antagonists attenuated the inhibitory effect of indomethacin on neutrophil infiltration without affecting the indomethacin-induced suppression of vascular permeability response. These results suggest that histamine produced in the inflammatory locus exerts a downward regulation of neutrophil infiltration through H2 receptors but does not play any significant role in the vascular permeability response. Furthermore, the inhibition by indomethacin of neutrophil infiltration might be ascribed to the increase in histamine level in the pouch fluid.

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References

Wang S, Zweiman B . Histamine suppression of human lymphocyte responses to mitogens. Cell Immunol. 1978; 36(1):28-36. DOI: 10.1016/0008-8749(78)90247-2. View

Horakova Z, Bayer B, Almeida A, BEAVEN M . Evidence that histamine does not participate in carrageenan-induced pleurisy in rat. Eur J Pharmacol. 1980; 62(1):17-25. DOI: 10.1016/0014-2999(80)90476-8. View

Tung R, Plaut M, Lichtenstein L . H2 antihistamines augment antigen-induced histamine release from human basophils in vitro. J Immunol. 1982; 129(5):2113-5. View

Dohlsten M, Kalland T, Sjogren H, Carlsson R . Histamine inhibits interleukin 1 production by lipopolysaccharide-stimulated human peripheral blood monocytes. Scand J Immunol. 1988; 27(5):527-32. DOI: 10.1111/j.1365-3083.1988.tb02379.x. View

Kheifets J, Thieme T, Mirkovich A, Ackerman N . The effects of histamine and serotonin on polymorphonuclear leukocyte accumulation in the rat. Eur J Pharmacol. 1986; 128(3):179-86. DOI: 10.1016/0014-2999(86)90764-8. View

Di Rosa M, Giroud J, Willoughby D . Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J Pathol. 1971; 104(1):15-29. DOI: 10.1002/path.1711040103. View

Ohuchi K, Sato H, Tsurufuji S . The effects of prostaglandin F2alpha on vascular permeability and collagen and non-collagen protein synthesis of preformed chronic carrageenin granuloma in rats. Biochem Pharmacol. 1977; 26(21):2049-53. DOI: 10.1016/0006-2952(77)90015-6. View

Hirasawa N, Ohuchi K, Kawarasaki K, Watanabe M, Tsurufuji S . Occurrence of histamine-production-increasing factor in the postanaphylactic phase of allergic inflammation. Int Arch Allergy Appl Immunol. 1989; 88(4):386-93. DOI: 10.1159/000234722. View

Williams T, Peck M . Role of prostaglandin-mediated vasodilatation in inflammation. Nature. 1977; 270(5637):530-2. DOI: 10.1038/270530a0. View

10.

Watanabe T, Taguchi Y, Sasaki K, TSUYAMA K, Kitamura Y . Increase in histidine decarboxylase activity in mouse skin after application of the tumor promoter tetradecanoylphorbol acetate. Biochem Biophys Res Commun. 1981; 100(1):427-32. DOI: 10.1016/s0006-291x(81)80114-3. View

11.

Hirasawa N, Ohuchi K, Watanabe M, Tsurufuji S . Mechanism of the inhibitory action of cyclooxygenase inhibitors on leukocyte infiltration: involvement of endogenous histamine. Eur J Pharmacol. 1987; 144(3):267-75. DOI: 10.1016/0014-2999(87)90379-7. View

12.

Capasso F, Dunn C, Yamamoto S, Willoughby D, Giroud J . Further studies on carrageenan-induced pleurisy in rats. J Pathol. 1975; 116(2):117-24. DOI: 10.1002/path.1711160208. View

13.

Ohuchi K, Hirasawa N, Watanabe M, Tsurufuji S . Pharmacological analysis of the vascular permeability response in the anaphylactic phase of allergic inflammation in rats. Eur J Pharmacol. 1985; 117(3):337-45. DOI: 10.1016/0014-2999(85)90007-x. View

14.

Hirasawa N, Ohuchi K, Watanabe M, Tsurufuji S . Role of endogenous histamine in postanaphylactic phase of allergic inflammation in rats. J Pharmacol Exp Ther. 1987; 241(3):967-73. View

15.

Busse W, Sosman J . Histamine inhibition of neutrophil lysosomal enzyme release: an H2 histamine receptor response. Science. 1976; 194(4266):737-8. DOI: 10.1126/science.185696. View

16.

Saeki K, Wake K, Yamasaki H . Inhibition of adjuvant arthritis by histamine. Arch Int Pharmacodyn Ther. 1976; 222(1):132-40. View

17.

Shore P, BURKHALTER A, COHN Jr V . A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther. 1959; 127:182-6. View

18.

LOWRY O, ROSEBROUGH N, FARR A, RANDALL R . Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1):265-75. View

19.

Dohlsten M, Sjogren H, Carlsson R . Histamine inhibits interferon-gamma production via suppression of interleukin 2 synthesis. Cell Immunol. 1986; 101(2):493-501. DOI: 10.1016/0008-8749(86)90160-7. View

20.

STOCHLA K, Maslinski S . Carrageenan-induced oedema in the rat paw - histamine participation. Agents Actions. 1982; 12(1-2):201-2. DOI: 10.1007/BF01965145. View