Multimodal Image-guided Enzyme/prodrug Cancer Therapy

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2006 Nov 23

PMID 17117842

Citations 14

Authors

Cong Li

Paul T Winnard Jr

Tomoyo Takagi

Dmitri Artemov

Zaver M Bhujwalla

Affiliations

Soon will be listed here.

Abstract

The conjugate of bacterial cytosine deaminase (bCD) and poly-l-lysine (PLL) that was functionalized with biotin, rhodamine, and Gd3+-DOTA was synthesized and characterized. It demonstrated high relaxivity, improved enzymatic specificity to prodrug 5-fluorocytosine, low cytotoxicity, efficient cell uptake, and high enzymatic stability in fresh mouse serum and human breast cancer cell culture.

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