Vascular Endothelial Growth Factor Biology: Clinical Implications for Ocular Treatments

Overview

Journal Br J Ophthalmol

Specialty Ophthalmology

Date 2006 Nov 23

PMID 17114590

Citations 61

Authors

R B Bhisitkul

Affiliations

Soon will be listed here.

Abstract

Decades of research on vascular endothelial growth factor (VEGF) have reached fruition with the recent development of intravitreal anti-VEGF treatments for exudative age-related macular degeneration. VEGF is a critical regulator of angiogenesis and vascular permeability with diverse roles, both pathological and physiological, during development and adulthood. The aim of this article is to review aspects of VEGF biology that may be relevant to the clinical use of anti-VEGF agents in ophthalmology: molecular characteristics and isoforms of VEGF; its roles in vasculogenesis, vascular maintenance and angiogenesis; systemic effects of VEGF inhibition; and properties of current anti-VEGF agents.

Citing Articles

45S5 Bioactive Glass-Ointment Positively Effects on Wound Healing in Rats by Regulating TNFα, Il-10, VEGF, and TGFβ.

Kirgiz O, Altug M, Ozkan H, Han M, Akcakavak G, Ozarslan A J Clin Lab Anal. 2024; 38(17-18):e25094.

PMID: 39235180 PMC: 11484740. DOI: 10.1002/jcla.25094.

Short Term Effect of Pre-Operative Anti-VEGF on Angiogenic and Fibrotic Profile of Fibrovascular Membranes of Proliferative Diabetic Retinopathy.

Fadakar K, Rahmani S, Tedeschi T, Lavine J, Fawzi A Invest Ophthalmol Vis Sci. 2024; 65(4):37.

PMID: 38652648 PMC: 11044842. DOI: 10.1167/iovs.65.4.37.

An Ensemble Docking Approach for Analyzing and Designing Aptamer Heterodimers Targeting VEGF.

Go Y, Kalathingal M, Rhee Y Int J Mol Sci. 2024; 25(7).

PMID: 38612876 PMC: 11012306. DOI: 10.3390/ijms25074066.

Intravitreal Anti-Vascular Endothelial Growth Factor Therapies for Retinal Disorders.

Hang A, Feldman S, Amin A, Ochoa J, Park S Pharmaceuticals (Basel). 2023; 16(8).

PMID: 37631054 PMC: 10458692. DOI: 10.3390/ph16081140.

High VEGF Concentrations Accelerate Human Trabecular Meshwork Fibrosis in a TAZ-Dependent Manner.

Sung M, Kim S, Eom G, Park S Int J Mol Sci. 2023; 24(11).

PMID: 37298577 PMC: 10253844. DOI: 10.3390/ijms24119625.

References

Lee J, Canny M, De Erkenez A, Krilleke D, Ng Y, Shima D . A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165. Proc Natl Acad Sci U S A. 2005; 102(52):18902-7. PMC: 1323181. DOI: 10.1073/pnas.0509069102. View

Baffert F, Le T, Sennino B, Thurston G, Kuo C, Hu-Lowe D . Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling. Am J Physiol Heart Circ Physiol. 2005; 290(2):H547-59. DOI: 10.1152/ajpheart.00616.2005. View

Avery R, Pieramici D, Rabena M, Castellarin A, Nasir M, Giust M . Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmology. 2006; 113(3):363-372.e5. DOI: 10.1016/j.ophtha.2005.11.019. View

Noma H, Minamoto A, Funatsu H, Tsukamoto H, Nakano K, Yamashita H . Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated with macular edema in branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2005; 244(3):309-15. DOI: 10.1007/s00417-004-1087-4. View

Demir R, Kayisli U, Cayli S, Huppertz B . Sequential steps during vasculogenesis and angiogenesis in the very early human placenta. Placenta. 2005; 27(6-7):535-9. DOI: 10.1016/j.placenta.2005.05.011. View

Rosenfeld P, Brown D, Heier J, Boyer D, Kaiser P, Chung C . Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006; 355(14):1419-31. DOI: 10.1056/NEJMoa054481. View

Brown D, Kaiser P, Michels M, Soubrane G, Heier J, Kim R . Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med. 2006; 355(14):1432-44. DOI: 10.1056/NEJMoa062655. View

Fung A, Rosenfeld P, Reichel E . The International Intravitreal Bevacizumab Safety Survey: using the internet to assess drug safety worldwide. Br J Ophthalmol. 2006; 90(11):1344-9. PMC: 1857484. DOI: 10.1136/bjo.2006.099598. View

Cunningham Jr E, Adamis A, Altaweel M, Aiello L, Bressler N, DAmico D . A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology. 2005; 112(10):1747-57. DOI: 10.1016/j.ophtha.2005.06.007. View

10.

Yonekura H, Sakurai S, Liu X, Migita H, Wang H, Yamagishi S . Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J Biol Chem. 1999; 274(49):35172-8. DOI: 10.1074/jbc.274.49.35172. View

11.

Ozaki H, Seo M, Ozaki K, Yamada H, Yamada E, Okamoto N . Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am J Pathol. 2000; 156(2):697-707. PMC: 1850054. DOI: 10.1016/S0002-9440(10)64773-6. View

12.

Miyamoto K, Khosrof S, Bursell S, Moromizato Y, Aiello L, Ogura Y . Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1). Am J Pathol. 2000; 156(5):1733-9. PMC: 1876909. DOI: 10.1016/S0002-9440(10)65044-4. View

13.

Zhang H, Scott P, Morbidelli L, Peak S, Moore J, Turley H . The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivo. Br J Cancer. 2000; 83(1):63-8. PMC: 2374542. DOI: 10.1054/bjoc.2000.1279. View

14.

Kasahara Y, Tuder R, Taraseviciene-Stewart L, Le Cras T, Abman S, Hirth P . Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest. 2000; 106(11):1311-9. PMC: 387249. DOI: 10.1172/JCI10259. View

15.

Ng Y, Rohan R, Sunday M, deMello D, DAmore P . Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn. 2001; 220(2):112-21. DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1093>3.0.CO;2-D. View

16.

Stacker S, Caesar C, Baldwin M, Thornton G, Williams R, Prevo R . VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med. 2001; 7(2):186-91. DOI: 10.1038/84635. View

17.

Karkkainen M, Makinen T, Alitalo K . Lymphatic endothelium: a new frontier of metastasis research. Nat Cell Biol. 2002; 4(1):E2-5. DOI: 10.1038/ncb0102-e2. View

18.

Stalmans I, Ng Y, Rohan R, Fruttiger M, Bouche A, Yuce A . Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest. 2002; 109(3):327-36. PMC: 150858. DOI: 10.1172/JCI14362. View

19.

Boyd S, Zachary I, Chakravarthy U, Allen G, Wisdom G, Cree I . Correlation of increased vascular endothelial growth factor with neovascularization and permeability in ischemic central vein occlusion. Arch Ophthalmol. 2002; 120(12):1644-50. DOI: 10.1001/archopht.120.12.1644. View

20.

Hudson P, Souriau C . Engineered antibodies. Nat Med. 2003; 9(1):129-34. DOI: 10.1038/nm0103-129. View