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Bone Marrow Mesenchymal Stem Cells Are Progenitors in Vitro for Inner Ear Hair Cells

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Date 2006 Nov 23
PMID 17113786
Citations 43
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Abstract

Stem cells have been demonstrated in the inner ear but they do not spontaneously divide to replace damaged sensory cells. Mesenchymal stem cells (MSC) from bone marrow have been reported to differentiate into multiple lineages including neurons, and we therefore asked whether MSCs could generate sensory cells. Overexpression of the prosensory transcription factor, Math1, in sensory epithelial precursor cells induced expression of myosin VIIa, espin, Brn3c, p27Kip, and jagged2, indicating differentiation to inner ear sensory cells. Some of the cells displayed F-actin positive protrusions in the morphology characteristic of hair cell stereociliary bundles. Hair cell markers were also induced by culture of mouse MSC-derived cells in contact with embryonic chick inner ear cells, and this induction was not due to a cell fusion event, because the chick hair cells could be identified with a chick-specific antibody and chick and mouse antigens were never found in the same cell.

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References
1.
Ma Q, Anderson D, Fritzsch B . Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation. J Assoc Res Otolaryngol. 2001; 1(2):129-43. PMC: 2504536. DOI: 10.1007/s101620010017. View

2.
Gowan K, Helms A, Hunsaker T, Collisson T, Ebert P, Odom R . Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons. Neuron. 2001; 31(2):219-32. DOI: 10.1016/s0896-6273(01)00367-1. View

3.
Jiang Y, Jahagirdar B, Reinhardt R, Schwartz R, Keene C, Ortiz-Gonzalez X . Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002; 418(6893):41-9. DOI: 10.1038/nature00870. View

4.
Wagers A, Sherwood R, Christensen J, Weissman I . Little evidence for developmental plasticity of adult hematopoietic stem cells. Science. 2002; 297(5590):2256-9. DOI: 10.1126/science.1074807. View

5.
Heller S, Bell A, Denis C, Choe Y, Hudspeth A . Parvalbumin 3 is an abundant Ca2+ buffer in hair cells. J Assoc Res Otolaryngol. 2002; 3(4):488-98. PMC: 3202440. DOI: 10.1007/s10162-002-2050-x. View