Tissue Engineering and Regenerative Medicine in the Field of Otorhinolaryngology

Overview

Journal Tissue Eng Regen Med

Date 2024 Jul 17

PMID 39017827

Authors

Se-Young Oh

Ha Yeong Kim

Soo Yeon Jung

Han Su Kim

Affiliations

Soon will be listed here.

Abstract

Background: Otorhinolaryngology is a medical specialty that focuses on the clinical study and treatments of diseases within head and neck regions, specifically including the ear, nose, and throat (ENT), but excluding eyes and brain. These anatomical structures play significant roles in a person's daily life, including eating, speaking as well as facial appearance and expression, thus greatly impacting one's overall satisfaction and quality of life. Consequently, injuries to these regions can significantly impact a person's well-being, leading to extensive research in the field of tissue engineering and regenerative medicine over many years.

Methods: This chapter provides an overview of the anatomical characteristics of otorhinolaryngologic tissues and explores the tissue engineering and regenerative medicine research in otology (ear), rhinology (nose), facial bone, larynx, and trachea.

Results And Conclusion: The integration of tissue engineering and regenerative medicine in otorhinolaryngology holds the promise of broadening the therapeutic choices for a wide range of conditions, ultimately improving quality of a patient's life.

References

Ma Y, Wise A, Shepherd R, Richardson R . New molecular therapies for the treatment of hearing loss. Pharmacol Ther. 2019; 200:190-209. PMC: 6626560. DOI: 10.1016/j.pharmthera.2019.05.003. View

Friedrich G, Dikkers F, Arens C, Remacle M, Hess M, Giovanni A . Vocal fold scars: current concepts and future directions. Consensus report of the Phonosurgery Committee of the European Laryngological Society. Eur Arch Otorhinolaryngol. 2013; 270(9):2491-507. DOI: 10.1007/s00405-013-2498-9. View

Lee J, Park H, Oh S, Lee J, Kim J, Kim H . Triple-layered polyurethane prosthesis with wrinkles for repairing partial tracheal defects. Laryngoscope. 2014; 124(12):2757-63. DOI: 10.1002/lary.24809. View

Choi J, Kim Y, Park J, Song E, Park J, Kim M . Controlled Release of Hepatocyte Growth Factor from MPEG-b-(PCL-ran-PLLA) Diblock Copolymer for Improved Vocal Fold Regeneration. Macromol Biosci. 2016; 17(2). DOI: 10.1002/mabi.201600163. View

Wolff J, K Sandor G, Miettinen A, Tuovinen V, Mannerstrom B, Patrikoski M . GMP-level adipose stem cells combined with computer-aided manufacturing to reconstruct mandibular ameloblastoma resection defects: Experience with three cases. Ann Maxillofac Surg. 2013; 3(2):114-25. PMC: 3814659. DOI: 10.4103/2231-0746.119216. View

Graupp M, Kiesler K, Friedrich G, Ainodhofer H, Gruber H, Kieslinger P . Vocal fold fibroblast response to growth factor treatment is age dependent: results from an in vitro study. J Voice. 2014; 28(4):420-3. DOI: 10.1016/j.jvoice.2013.11.005. View

Ou M, Li Q, Ling X, Yao J, Mo X . Cocktail Formula and Application Prospects for Oral and Maxillofacial Organoids. Tissue Eng Regen Med. 2022; 19(5):913-925. PMC: 9477993. DOI: 10.1007/s13770-022-00455-3. View

Kada S, Hamaguchi K, Ito J, Omori K, Nakagawa T . Bone Marrow Stromal Cells Accelerate Hearing Recovery via Regeneration or Maintenance of Cochlear Fibrocytes in Mouse Spiral Ligaments. Anat Rec (Hoboken). 2019; 303(3):478-486. DOI: 10.1002/ar.24063. View

Zhang S, Qiang R, Dong Y, Zhang Y, Chen Y, Zhou H . Hair cell regeneration from inner ear progenitors in the mammalian cochlea. Am J Stem Cells. 2020; 9(3):25-35. PMC: 7364385. View

10.

Nimeskern L, Pleumeekers M, Pawson D, Koevoet W, Lehtoviita I, Soyka M . Mechanical and biochemical mapping of human auricular cartilage for reliable assessment of tissue-engineered constructs. J Biomech. 2015; 48(10):1721-9. DOI: 10.1016/j.jbiomech.2015.05.019. View

11.

Kamil S, Vacanti M, Aminuddin B, Jackson M, Vacanti C, Eavey R . Tissue engineering of a human sized and shaped auricle using a mold. Laryngoscope. 2004; 114(5):867-70. DOI: 10.1097/00005537-200405000-00015. View

12.

Park J, Kim I, Lee W, Kim H . Evaluation of the regenerative capacity of stem cells combined with bone graft material and collagen matrix using a rabbit calvarial defect model. J Periodontal Implant Sci. 2023; 53(6):467-477. PMC: 10761282. DOI: 10.5051/jpis.2204880244. View

13.

Im D, Paskhover B, Staffenberg D, Jarrahy R . Current management of microtia: a national survey. Aesthetic Plast Surg. 2013; 37(2):402-8. DOI: 10.1007/s00266-012-0008-x. View

14.

Simorgh S, Alizadeh R, Shabani R, Karimzadeh F, Seidkhani E, Majidpoor J . Olfactory mucosa stem cells delivery via nasal route: a simple way for the treatment of Parkinson disease. Neurotox Res. 2021; 39(3):598-608. DOI: 10.1007/s12640-020-00290-1. View

15.

REICH A, Lerman J . Teflon laryngoplasty: an acoustical and perceptual study. J Speech Hear Disord. 1978; 43(4):496-505. DOI: 10.1044/jshd.4304.496. View

16.

Handschel J, Hassanyar H, Depprich R, Ommerborn M, Sproll K, Hofer M . Nonvascularized iliac bone grafts for mandibular reconstruction--requirements and limitations. In Vivo. 2011; 25(5):795-9. View

17.

Jette M, Hayer S, Thibeault S . Characterization of human vocal fold fibroblasts derived from chronic scar. Laryngoscope. 2013; 123(3):738-45. PMC: 3584344. DOI: 10.1002/lary.23681. View

18.

Vogel G . Trachea transplants test the limits. Science. 2013; 340(6130):266-8. DOI: 10.1126/science.340.6130.266. View

19.

Bouyer M, Garot C, Machillot P, Vollaire J, Fitzpatrick V, Morand S . 3D-printed scaffold combined to 2D osteoinductive coatings to repair a critical-size mandibular bone defect. Mater Today Bio. 2021; 11:100113. PMC: 8173095. DOI: 10.1016/j.mtbio.2021.100113. View

20.

Goldstein J, Paliga J, Bartlett S . Cranioplasty: indications and advances. Curr Opin Otolaryngol Head Neck Surg. 2013; 21(4):400-9. DOI: 10.1097/MOO.0b013e328363003e. View