MicroRNAs and Genomic Instability

Overview

Journal Semin Cancer Biol

Specialty Oncology

Date 2006 Nov 23

PMID 17113784

Citations 37

Authors

Konrad Huppi

Natalia Volfovsky

Mark Mackiewicz

Timothy Runfola

Tamara L Jones

Scott E Martin

Robert Stephens

Natasha J Caplen

Affiliations

Soon will be listed here.

Abstract

A new species of non-coding RNA, microRNAs (miRNAs) has been identified that may regulate the expression of as many as one third to one half of all protein encoding genes. MicroRNAs are found throughout mammalian genomes, but an association between the location of these miRNAs and regions of genomic instability (or fragile sites) in humans has been suggested [1]. In this review we discuss the possible role of altered miRNA expression on human cancer and conduct an analysis correlating the physical location of murine miRNAs with sites of genetic alteration in mouse models of cancer.

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