Group B Streptococcus: Global Incidence and Vaccine Development

Overview

Journal Nat Rev Microbiol

Specialties Infectious Diseases
Microbiology

Date 2006 Nov 8

PMID 17088932

Citations 122

Authors

Atul Kumar Johri

Lawrence C Paoletti

Philippe Glaser

Meenakshi Dua

Puja Kumari Sharma

Guido Grandi

Rino Rappuoli

Affiliations

Soon will be listed here.

Abstract

An ongoing public health challenge is to develop vaccines that are effective against infectious diseases that have global relevance. Vaccines against serotypes of group B Streptococcus (GBS) that are prevalent in the United States and Europe are not optimally efficacious against serotypes common to other parts of the world. New technologies and innovative approaches are being used to identify GBS antigens that overcome serotype-specificity and that could form the basis of a globally effective vaccine against this opportunistic pathogen. This Review highlights efforts towards this goal and describes a template that can be followed to develop vaccines against other bacterial pathogens.

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