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Antibiotic Magainins Exert Cytolytic Activity Against Transformed Cell Lines Through Channel Formation

Overview
Journal Proc Natl Acad Sci U S A
Specialty Science
Date 1991 May 1
PMID 1708887
Citations 85
Authors
R A Cruciani
J L Barker
M Zasloff
H C Chen
O Colamonici
Affiliations
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Abstract

Magainins are an ionophoric class of vertebrate peptides with antibiotic activity against various microorganisms. Here we show that magainin 2 and synthetic analogues can rapidly and irreversibly lyse hematopoietic tumor and solid tumor target cells with a relative cytotoxic potency that parallels their antibacterial efficacy and at concentrations that are relatively nontoxic to well-differentiated cells. The cytotoxicity is prevented by cell depolarization. Magainins represent a natural cytolytic agent in vertebrates and may provide another therapeutic strategy for certain tumors.

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